- ABclonal always adheres to the customer first business philosophy. Through accumulation of long years experiment, constantly optimization of the synthesis conditions and the purification technology, we already have a mature method of stapled peptide synthesis to provide high quality stapled peptides fully meeting the needs of customers in different kinds of research and development area.
- The synthesis difference between stapled peptide and the normal linear peptide lies in being introduced the two non natural amino acids containing a-methyl and a-alkenyl in the process of solid phase synthesis.Then the two non natural amino acids occur olefin metathesis cyclization to form stable a-helix conformation of the carbon to synthesize stapled peptide.
- The two pictures A and B are non natural amino acids with two different structures of containing a-methyl and a-alkenyl. Please focus on the below synthesis method of these amino acids (FigC).
- The synthetic route of stapled peptide
- Long years experiment/li>
- Constantly optimization
- Enhance receptor affinity and efficacy
- Increased cell permeability
- Decrease proteolysis hence increased bio-activities
2-3weeks, 1-2 weeks for urgent.
MS, HPLC and COA after each synthesis step for free.
Peptide is delivered in lyophilized form.
Problems submitted in 1-2 weeks, we provide free-issue retest ,and refund for unqualified products.Ineligible goods retesting in 1-3 month free.
Our technical support permanent, customers enjoy experienced technical experts one to one service.
Certificate of Analysis includes MS and HPLC analyses performed after the completion of peptide synthesis, purification, and QC (quality control) steps. These analyses are followed by independent QA (quality assurance) procedures, guaranteeing the highest quality of peptides.
- Chromatography (HPLC, TLC, GC, IC)
- Chromatography coupled to MS (LC-MS/ESI)
- Spectroscopy (UV-Vis, IR, NMR)
- Metallic Analysis (AAS, ICP, ICP-MS)
- Elemental Analysis
- Titration (Acid-Base Titration, Karl Fischer Titration)
- Amino acid analysis