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Human XEDAR/EDA2R Gene ORF cDNA clone expression plasmid

Catalog No:HG11845-UT
NCBI RefSeq:894 bp
Type:Expression-Ready ORF Clones
Gene ID:

Cynomolgus CD19/B4/CVID3 Gene Plasmid Map

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Tumor necrosis factor receptor superfamily member 27, also known as X-linked ectodysplasin-A2 receptor, EDA-A2 receptor, EDA2R, XEDAR and TNFRSF27, is a single-pass type I II membrane protein. TNFRSF27 / EDA2R contains three TNFR-Cys repeats. It is a new member of the tumor necrosis factor receptor family that has been shown to be highly expressed in ectodermal derivatives during embryonic development and binds to ectodysplasin-A2 (EDA-A2). TNFRSF27 / EDA2R is a receptor for EDA isoform A2, but not for EDA isoform A1. TNFRSF27 / EDA2R mediates the activation of the NF-kappa-B and JNK pathways. The activation seems to be mediated by binding to TRAF3 and TRAF6. Ectodysplasin, a member of the tumor necrosis factor family, is encoded by the anhidrotic ectodermal dysplasia EDA gene. Mutations in EDA give rise to a clinical syndrome characterized by loss of hair, sweat glands, and teeth. EDA-A1 and EDA-A2 are two isoforms of ectodysplasin that differ only by an insertion of two amino acids. This insertion functions to determine receptor binding specificity, such that EDA-A1 binds only the receptor EDAR, whereas EDA-A2 binds only the related, but distinct, X-linked ectodysplasin-A2 receptor (XEDAR).

Human XEDAR/EDA2R Gene ORF cDNA clone expression plasmid Product information

Molecule NameEDA2R
RefSeq ORF Size894 bp
cDNA DescriptionHuman XEDAR/EDA2R Gene ORF cDNA clone expression plasmid (HG11845-UT) - available for purchase from ABclonal - allows for easy subcloning of the ORF (pCMV3-untagged Vector) to other plasmid vectors.
Restriction siteHindIII + XbaI (6.1kb + 0.89kb)
Tag Sequence
Sequence DescriptionIdentical with the Gene Bank Ref. ID sequence.
PromoterEnhanced CMV mammalian cell promoter
Antibiotic in E.coliAmpicillin
Antibiotic in mammalian cellHygromycin
Shipping carrierEach tube contains lyophilized plasmid.
StorageThe lyophilized plasmid can be stored at ambient temperature for three months.

Human XEDAR/EDA2R Gene ORF cDNA clone expression plasmid images

Cynomolgus CD19/B4/CVID3 Gene Plasmid Map

Neucleotide sequence and amino acid sequence


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