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Human ICAM-1/CD54 Gene ORF cDNA clone expression plasmid, C-OFPSpark tag (HG10346-ACR)

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Overview

Product nameHuman ICAM-1/CD54 Gene ORF cDNA clone expression plasmid, C-OFPSpark tag
Catalog No.HG10346-ACR
NCBI RefSeq1599 bp
TypeExpression-Ready ORF Clones
Intercellular adhesion molecule-1 (ICAM-1, or CD54) is a 90 kDa member of the immunoglobulin (Ig) superfamily and is critical for the firm arrest and transmigration of leukocytes out of blood vessels and into tissues. ICAM-1 is constitutively present on endothelial cells, but its expression is increased by proinflammatory cytokines. The endothelial expression of ICAM-1 is increased in atherosclerotic and transplant-associated atherosclerotic tissue and in animal models of atherosclerosis. Additionally, ICAM-1 has been implicated in the progression of autoimmune diseases. ICAM-1 is a ligand for LFA-1(integrin). When activated, leukocytes bind to endothelial cells via ICAM-1/LFA-1 interaction and then transmigrate into tissues. Presence with heavy glycosylation and other structural characteristics, ICAM-1 possesses binding sites for a number of immune-associated ligands and serves as the binding site for entry of the major group of human Rhinovirus (HRV) into various cell types. ICAM-1 also becomes known for its affinity for Plasmodium falciparum-infected erythrocytes (PFIE), providing more of a role in infectious disease. Previous studies have shown that ICAM-1 is involved in inflammatory reactions and that a defect in ICAM-1 gene inhibits allergic contact hypersensitivity.
Molecule nameICAM1
RefSeq ORF size1599 bp
cDNA descriptionHuman ICAM-1/CD54 Gene ORF cDNA clone expression plasmid, C-OFPSpark tag (HG10346-ACR) - available for purchase from ABclonal - allows for easy subcloning of the ORF (pCMV3-C-OFPSpark Vector) to other plasmid vectors.
SynonymBB2, CD54, ICAM-1, P3.58
VectorpCMV3-C-OFPSpark
PlasimidpCMV3-ICAM1-OFPSpark
Restriction siteKpnI + XbaI (6kb + 2.29kb)
Tag SsequenceOFPSpark Tag: GATAGCACTGAG……CACCTGTTCCAG
Sequence descriptionIdentical with the Gene Bank Ref. ID sequence.
Sequencing primersT7(TAATACGACTCACTATAGGG) BGH(TAGAAGGCACAGTCGAGG)
PromoterEnhanced CMV mammalian cell promoter
Antibiotic in E.coliKanamycin
Antibiotic in mammalian cellHygromycin
Shipping carrierEach tube contains lyophilized plasmid.
StorageThe lyophilized plasmid can be stored at ambient temperature for three months.

GFP Gene Plasmid Map

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