|Product name||Human Cyclophilin A Gene ORF cDNA clone expression plasmid, C-Myc tag|
|NCBI RefSeq||498 bp|
|Type||Expression-Ready ORF Clones|
Mouse peptidyl-prolyl cis-trans isomerase A, also known as PPIase A, Rotamase A, Cyclophilin A, Cyclosporin A-binding protein, PPIA and CYPA, is a cytoplasm protein which belongs to the cyclophilin-type PPIase family and PPIase A subfamily. Cyclophilins (CyPs) are a family of proteins found in organisms ranging from prokaryotes to humans. These molecules exhibit peptidyl-prolyl isomerase activity, sµggesting that they influence the conformation of proteins in cells. PPIA / Cyclophilin A accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. PPIA / Cyclophilin A is secreted by vascular smooth muscle cells in response to inflammatory stimuli, and could thus contribute to atherosclerosis. It is not essential for mammalian cell viability. PPIA / Cyclophilin A can interact with several HIV proteins, including p55 gag, Vpr, and capsid protein, and has been shown to be necessary for the formation of infectious HIV virions.
|RefSeq ORF size||498 bp|
|cDNA description||Human Cyclophilin A Gene ORF cDNA clone expression plasmid, C-Myc tag (HG10436-CM) - available for purchase from ABclonal - allows for easy subcloning of the ORF (pCMV3-C-Myc Vector) to other plasmid vectors.|
|Synonym||CYPA, CYPH, HEL-S-69p|
|Tag Ssequence||Myc Tag Sequence: GAGCAGAAACTCATCTCAGAAGAGGATCTG|
|Sequencing primers||T7(TAATACGACTCACTATAGGG) BGH(TAGAAGGCACAGTCGAGG)|
|Promoter||Enhanced CMV mammalian cell promoter|
|Antibiotic in E.coli||Kanamycin|
|Antibiotic in mammalian cell||Hygromycin|
|Shipping carrier||Each tube contains lyophilized plasmid.|
|Storage||The lyophilized plasmid can be stored at ambient temperature for three months.|
Inquire About This Product
Submit your question about HG10436-CM below and we will get back to you within one business day.
Alternatively, call us at 888.754.5670.