|Product name||Cynomolgus TNFSF14/LIGHT/CD258 Gene ORF cDNA clone expression plasmid, C-GFPSpark tag|
|NCBI RefSeq||723 bp|
|Type||Expression-Ready ORF Clones|
LIGHT, also known as TNFSF14 or CD258, is a newly identified member of the TNF superfamily (TNFSF14) that is expressed by activated T lymphocytes, monocytes, granulocytes, spleen cells, and immature dendritic cells. TNFSF14 / LIGHT / CD258 is a type II transmembrane protein that is known to bind 2 membrane-bound TNFSF signaling receptors: HVEM, which is predominantly expressed by T cells, and lymphotoxin β receptor (LTβR), which is expressed by stromal cells and nonlymphoid hematopoietic cells. TNFSF14 / LIGHT / CD258 also binds to a soluble nonsignaling receptor, decoy receptor 3 (DcR3), which can modulate the function of LIGHT in vivo. TNFSF14 / LIGHT / CD258 can also costimulate T cell responses via HVEM, which is constitutively expressed in most lymphocyte subpopulations, including CD4+ and CD8+ T cells. In addition, TNFSF14 / LIGHT / CD258 has been shown to suppress tumor formation in vivo and to induce tumor cell apoptosis via the up-regulation of intercellular adhesion molecule 1 and an increased lymphocyte adhesion to cancer cells. Thus, TNFSF14 / LIGHT / CD258 is being actively investigated as a possible basis for cancer treatment.
|RefSeq ORF size||723 bp|
|cDNA description||Cynomolgus TNFSF14/LIGHT/CD258 Gene ORF cDNA clone expression plasmid, C-GFPSpark tag (CG90090-ACG) - available for purchase from ABclonal - allows for easy subcloning of the ORF (pCMV3-C-GFPSpark Vector) to other plasmid vectors.|
|Tag Ssequence||GFPSpark: GTGAGCAAGGGC……GAGCTGTACAAG|
|Sequencing primers||T7(TAATACGACTCACTATAGGG) BGH(TAGAAGGCACAGTCGAGG) |
|Promoter||Enhanced CMV mammalian cell promoter|
|Antibiotic in E.coli||Kanamycin|
|Antibiotic in mammalian cell||Hygromycin|
|Shipping carrier||Each tube contains lyophilized plasmid.|
|Storage||The lyophilized plasmid can be stored at ambient temperature for three months.|
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