Product Type > Proteins

Recombinant Human IL-17/IL-17A Protein (RP00395)

Datasheet

Overview

Product name Recombinant Human IL-17/IL-17A Protein
Catalog No. RP00395
Description Recombinant Human IL-17/IL-17A Protein is produced by Human Cell expression system. The target protein is expressed with sequence (Gly24-Ala155) of human IL-17/IL-17A (Accession #Q16552) fused with a 6×His tag at the C-terminus.
Bio-Activity Measured by its ability to induce IL-6 secretion by NIH?3T3 mouse embryonic fibroblast cells. The ED50 for this effect is typically 0.5-2 ng/mL.
Purity > 95% by SDS-PAGE.
Endotoxin < 1 EU/μg of the protein by LAL method.
Formulation Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH7.4.Contact us for customized product form or formulation.
Species Human
This protein is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis.
Synonym IL17A; CTLA-8; CTLA8; IL-17; IL-17A; IL17; interleukin-17A; CTLA-8; CTLA8; IL-17; IL-17A; IL17
Expressed Host HEK293 cells
Tag C-6×His
Swiss-Prot Q16552
Gene ID 3605
Storage Store the lyophilized protein at -20°C to -80 °C for long term.
After reconstitution, the protein solution is stable at -20 °C for 3 months, at 2-8 °C for up to 1 week.
Reconstitution Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water.

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