Product Type > Proteins

Recombinant Human IGFBP-4 Protein (RP00390)

Datasheet

Overview

Product name Recombinant Human IGFBP-4 Protein
Catalog No. RP00390
Description Recombinant Human IGFBP-4 Protein is produced by Human Cell expression system. The target protein is expressed with sequence (Asp22-Glu258) of human IGFBP-4 (Accession #P22692) fused with a 6×His tag at the C-terminus.
Bio-Activity Measured by its ability to inhibit the biological activity of IGF-II on MCF-7 human breast cancer cells. Karey, K.P. et al. (1988) Cancer Research 48:4083. The ED50 for this effect is 0.03-0.09 μg/mL in the presence of 14 ng/mL recombinant human IGF-II.
Purity > 95% by SDS-PAGE.
Endotoxin < 1 EU/μg of the protein by LAL method.
Formulation Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.2.Contact us for customized product form or formulation.
Species Human
This protein is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma in both glycosylated and non-glycosylated forms. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors.
Synonym IGFBP4; BP-4; HT29-IGFBP; IBP4; IGFBP-4
Expressed Host HEK293 cells
Tag C-6×His
Swiss-Prot P22692
Gene ID 3487
Storage Store the lyophilized protein at -20°C to -80 °C for long term.
After reconstitution, the protein solution is stable at -20 °C for 3 months, at 2-8 °C for up to 1 week.
Reconstitution Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water.

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