Product Type > Proteins

Recombinant Human FGF R3 Protein (RP00371)

Datasheet

Overview

Product name Recombinant Human FGF R3 Protein
Catalog No. RP00371
Description Recombinant Human FGF R3 Protein is produced by Human Cell expression system. The target protein is expressed with sequence (Glu23-Gly375) of human FGF R3 (Accession #P22607) fused with a 6×His tag at the C-terminus.
Purity > 95% by SDS-PAGE.
Endotoxin < 1 EU/μg of the protein by LAL method.
Formulation Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.Contact us for customized product form or formulation.
Species Human
This protein belongs a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in this gene lead to craniosynostosis and multiple types of skeletal dysplasia. Three alternatively spliced transcript variants that encode different protein isoforms have been described.
Synonym ACH; CD333; CEK2; HSFGFR3EX; JTK4; FGFR3
Expressed Host HEK293 cells
Tag C-6×His
Swiss-Prot P22607
Gene ID 2261
Storage Store the lyophilized protein at -20°C to -80 °C for long term.
After reconstitution, the protein solution is stable at -20 °C for 3 months, at 2-8 °C for up to 1 week.
Reconstitution Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water.

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