|Product name||Recombinant Human CTLA-4/CD152 Protein|
|Description||Recombinant Human CTLA-4/CD152 Protein is produced by Human Cell expression system. The target protein is expressed with sequence (Lys36-Asp161) of human CTLA-4/CD152 (Accession #P16410) fused with a 6×His tag at the C-terminus.|
This protein is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in This protein have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases.
|Synonym||ALPS5; CD; CD152; CELIAC3; CTLA-4; GRD4; GSE; IDDM12|
|Expressed Host||Human Cells|
|Tag||6×His tag at the C-terminus|
|Purity||> 95% by SDS-PAGE.|
|Endotoxin||< 1 EU/μg of the protein by LAL method. |
|Formulation||Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.|
|Storage||Store the lyophilized protein at -20°C to -80 °C for long term.|
After reconstitution, the protein solution is stable at -20 °C for 3 months, at 2-8 °C for up to 1 week.
|Reconstitution||Reconstitute to a concentration of 0.1-0.5 mg/mL in 1X PBS.|
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