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Recombinant Human CD40 Ligand/CD154/CD40L/TNFSF5 Protein (RP00329)

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Overview

Product nameRecombinant Human CD40 Ligand/CD154/CD40L/TNFSF5 Protein
Catalog No.RP00329
DescriptionRecombinant Human CD40 Ligand/CD154/CD40L/TNFSF5 Protein is produced by Human Cell expression system. The target protein is expressed with sequence (Met113-Leu261) of human CD40 Ligand/CD154/CD40L/TNFSF5 (Accession #P29965).
Bio-ActivityMeasured in a cell proliferation assay using B cell-enriched peripheral blood mononuclear cells (PBMC) in the presence of IL-4. The ED50 for this effect is 1-3 μg/mL in the presence of 20 ng/mL of recombinant human IL-4.
Swiss portP29965
Gene ID959
SpeciesHuman
This protein is expressed on the surface of T cells. It regulates B cell function by engaging CD40 on the B cell surface. A defect in this gene results in an inability to undergo immunoglobulin class switch and is associated with hyper-IgM syndrome.
SynonymCD154; CD40L; gp39; hCD40L; HIGM1; IGM; IMD3; T-BAM; TNFSF5; TRAP
Expressed HostHuman cells
TagNo tag
Purity> 95% by SDS-PAGE.
Endotoxin< 1 EU/μg of the protein by LAL method.
FormulationLyophilized from a 0.2 μm filtered solution of 20 mM PB, 200 mM NaCl, 0.1 mM EDTA, pH 7.0.
StorageStore the lyophilized protein at -20°C to -80 °C for long term.
After reconstitution, the protein solution is stable at -20 °C for 3 months, at 2-8 °C for up to 1 week.
ReconstitutionReconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water.

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