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Recombinant Human B7-H3/CD276 Protein (RP00327)

Datasheet

Overview

Product nameRecombinant Human B7-H3/CD276 Protein
Catalog No.RP00327
DescriptionRecombinant Human B7-H3/CD276 Protein is produced by Human Cell expression system. The target protein is expressed with sequence (Leu29-Thr461) of human B7-H3/CD276 (Accession #Q5ZPR3) fused with a 6×His tag at the C-terminus.
Swiss portQ5ZPR3
Gene ID80381
SpeciesHuman
This protein belongs to the immunoglobulin superfamily, and thought to participate in the regulation of T-cell-mediated immune response. Studies show that while the transcript of this gene is ubiquitously expressed in normal tissues and solid tumors, the protein is preferentially expressed only in tumor tissues. Additionally, it was observed that the 3' UTR of this transcript contains a target site for miR29 microRNA, and there is an inverse correlation between the expression of this protein and miR29 levels, suggesting regulation of expression of this gene product by miR29. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Synonym4Ig-B7-H3; B7-H3; B7H3; B7RP-2
Expressed HostHuman cells
Tag6×His tag at the C-terminus
Purity> 95% by SDS-PAGE.
Endotoxin< 1 EU/μg of the protein by LAL method.
FormulationLyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
StorageStore the lyophilized protein at -20°C to -80 °C for long term.
After reconstitution, the protein solution is stable at -20 °C for 3 months, at 2-8 °C for up to 1 week.
ReconstitutionReconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water.

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