Product Type > Proteins

Recombinant Human IL-1R2/IL-1RT2/CD121b Protein (RP01028)

Datasheet

Overview

Product name Recombinant Human IL-1R2/IL-1RT2/CD121b Protein
Catalog No. RP01028
Description Recombinant Human IL-1R2/IL-1RT2/CD121b Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Met1-Glu343) of human IL1R2 (Accession #NP_004624.1) fused with a 6×His tag at the C-terminus.
Bio-Activity Measured by its binding ability in a functional ELISA. Immobilized Recombinant Human IL1R2 at 2 μg/mL (100 μL/well) can bind Human IL1RA with a linear range of 31.25-43.5 ng/mL.
Purity > 95% by SDS-PAGE.
Endotoxin < 0.1 EU/μg of the protein by LAL method.
Formulation Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.Contact us for customized product form or formulation.
Species Human
Non-signaling receptor for IL1A, IL1B and IL1RN. Reduces IL1B activities. Serves as a decoy receptor by competetive binding to IL1B and preventing its binding to IL1R1. Also modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors.
Synonym IL1R2; CD121b; CDw121b; IL-1R-2; IL-1RT-2; IL-1RT2; IL1R2c; IL1RB
Expressed Host HEK293 cells
Tag C-His
Swiss-Prot P27930
Gene ID 7850
Storage Store the lyophilized protein at -20°C to -80 °C for long term.
After reconstitution, the protein solution is stable at -20 °C for 3 months, at 2-8 °C for up to 1 week.
Reconstitution Centrifuge the vial before opening. Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. Avoid votex or vigorously pipetting the protein. For long term storage, it is recommended to add a carrier protein or stablizer (e.g. 0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose), and aliquot the reconstituted protein solution to minimize free-thaw cycles.

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