Product Type > Proteins

Recombinant Mouse TNFRSF21/DR6 Protein (RP00600)

Datasheet

Overview

Product name Recombinant Mouse TNFRSF21/DR6 Protein
Catalog No. RP00600
Description Recombinant Mouse TNFRSF21/DR6 Protein is produced by Human cells expression system. The target protein is expressed with sequence (Gln42-His349) of mouse TNFRSF21/DR6 (Accession #Q9EPU5) fused with an Fc, 6×His tag at the C-terminus.
Purity > 95% by SDS-PAGE.
Endotoxin < 1 EU/μg of the protein by LAL method.
Formulation Lyophilized from a 0.2 μM filtered solution of PBS,pH 7.4Contact us for customized product form or formulation.
Species Mouse
Tumor necrosis factor receptor superfamily member 21(DR6) is a single-pass type I membrane protein andcontains 1 death domain and 4 TNFR-Cys repeats. The protein may activate NF-kappa-B and promoteapoptosis and it may activate JNK and be involved in T-cell differentiation.It is required for both normal cellbody death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP). N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6).
Synonym Tumor necrosis factor receptor superfamily member 21; Death receptor 6; Tnfrsf21; CD358; BM-018; DR6
Expressed Host HEK293 cells
Tag C-Fc & 6×His
Swiss-Prot Q9EPU5
Gene ID 94185
Storage Store the lyophilized protein at -20°C to -80 °C for long term.
After reconstitution, the protein solution is stable at -20 °C for 3 months, at 2-8 °C for up to 1 week.
Reconstitution Reconstitute to a concentration of 0.1-0.5 mg/mL in 1X PBS.

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