Overview
Product name |
Recombinant Mouse S100B/S100 Calcium Binding Protein B Protein |
Catalog No. |
RP00687 |
Description |
Recombinant Mouse S100B/S100 Calcium Binding Protein B Protein is produced by E. coli expression system. The target protein is expressed with sequence (Met1-Glu92) of mouse S100B/S100 Calcium Binding Protein B (Accession #P50114) fused with a 6×His tag at the C-terminus. |
Purity |
> 95% by SDS-PAGE. |
Endotoxin |
< 1 EU/μg of the protein by LAL method. |
Formulation |
Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH7.4.Contact us for customized product form or formulation. |
Species |
Mouse |
Background
S100-B, is an acidic protein with a molecular weight of 21 kDa belonging to the S100 family. S100-B containstwo EF-hand-type calcium-binding motifs separated by a hinge region with a hydrophobic cleft. S100-B playsan important role in neurodevelopment, differentiation, and brain construction. S100-B has neuroprotectiveeffects, but at high concentrations S100-B is neurotoxic. Extracellular concentration of S100-B increasesfollowing brain damage, which easily penetrates into cerebrospinal fluid in brain damage and then into theblood. S100-B is expressed and produced by astrocytes in vertebrate brains and in the CNS, and the astrocytesare the major cells producing S100-B protein in gray matter, as well as oligodendrocytes are the predominantS100-B in protein producing cells in white matter. The major advantage of using S100-B is that elevations inserum or CSF levels provide a sensitive measure for determining CNS injury at the molecular level before grosschanges develop, enabling timely delivery of crucial medical intervention before irreversible damage occurs. Inaddition, S100-B, which is also present in Mouse melanocytes, is a reliable marker for melanoma malignancyboth in bioptic tissue and in serum.
Product information
Synonym |
Protein S100-B; S-100 protein beta chain; S-100 protein subunit beta; S100 calcium-bindingprotein B; S100b; S100 beta; S100 calcium binding protein B |
Expressed Host |
E. coli |
Tag |
C-6×His |
Swiss-Prot |
P50114 |
Gene ID |
20203 |
Usage guide
Storage |
Store the lyophilized protein at -20°C to -80 °C for long term. After reconstitution, the protein solution is stable at -20 °C for 3 months, at 2-8 °C for up to 1 week. |
Reconstitution |
Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. |
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* For research use only. Not for therapeutic or diagnostic
purposes.