Product Type > Proteins

Recombinant Mouse PD-L1/B7-H1/CD274 Protein (RP00655)

Datasheet

Overview

Product name Recombinant Mouse PD-L1/B7-H1/CD274 Protein
Catalog No. RP00655
Description Recombinant Mouse PD-L1/B7-H1/CD274 Protein is produced by Human cells expression system. The target protein is expressed with sequence (Phe19-Thr238) of mouse PD-L1/B7-H1/CD274 (Accession #Q9EP73) fused with a 6×His tag at the C-terminus.
Purity > 95% by SDS-PAGE.
Endotoxin < 1 EU/μg of the protein by LAL method.
Formulation Lyophilized from a 0.2 μM filtered solution of 20mM PB, 150mM NaCl, pH 7.4Contact us for customized product form or formulation.
Species Mouse
Mouse Programmed cell death 1 ligand 1(Cd274, PD-L1), is a member of the growing B7 family of immuneproteins.It involved in the costimulatory signal essential for T-cell proliferation and IFNG production in aPDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycleprogression and cytokine production.B7-H1 has been identified as one of two ligands for programmed death1(PD1), a member of the CD28 family of immunoreceptors. B7-H1 is constitutively expressed in several organssuch as heart, skeletal muscle B7-H1 expression is upregulated in a small fraction of activated T and B cells anda much larger fraction of activated monocytes. The costimulatory function of B7-H1 is critical for enhancingmaturation and differentiation of T-cells in lymphoid organs.B7-H1 expression is also induced in dendritic cellsand keratinocytes after IFN gamma stimulation. Interaction of B7-H1 with PD1 results in inhibition of TCR-mediated proliferation and cytokine production. The B7-H1:PD1 pathway is involved in the negative regulationof some immune responses and may play an important role in the regulation of peripheral tolerance.
Synonym PD-; B7h1; Pdl1; Pdcd1l; Pdcd1l1; Pdcd1lg1; A530045L16Rik; CD274
Expressed Host HEK293 cells
Tag C-6×His
Swiss-Prot Q9EP73
Gene ID 60533
Storage Store the lyophilized protein at -20°C to -80 °C for long term.
After reconstitution, the protein solution is stable at -20 °C for 3 months, at 2-8 °C for up to 1 week.
Reconstitution Reconstitute to a concentration of 0.1-0.5 mg/mL in 1X PBS.

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