Product Type > Proteins

Recombinant Mouse IL-18/IL-1F4 Protein (RP00663)

Datasheet

Overview

Product name Recombinant Mouse IL-18/IL-1F4 Protein
Catalog No. RP00663
Description Recombinant Mouse IL-18/IL-1F4 Protein is produced by E. coli expression system. The target protein is expressed with sequence (Asn36-Ser192) of mouse IL-18/IL-1F4 (Accession #P70380) fused with an initial Met at the N-terminus and a 6×His tag at the N-terminus.
Purity > 95% by SDS-PAGE.
Endotoxin < 1 EU/μg of the protein by LAL method.
Formulation Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.Contact us for customized product form or formulation.
Species Mouse
Interleukin-18 (IL-18) is a protein which belongs to the IL-1 family. It is expressed as a 24 kDa precursor byendothelial and epithelial cells, keratinocytes, gamma δ T cells, and phagocytes. Mature mouse IL-18 shares63% and 91% amino acid sequence identity with mouse and rat IL-18, respectively. IL-18 binds to the widelyexpressed IL-18 R alpha which recruits IL-18 R beta to form the signaling receptor complex. Its bioactivity isnegatively regulated by interactions with IL-18 binding proteins and virally encoded IL-18BP homologs. Itaugments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helpertype I cells. In the presence of IL-12 or IL-15, IL-18 enhances anti-viral Th1 immune responses by inducing IFN-gamma production and the cytolytic activity of CD8+ T cells and NK cells. In the absence of IL-12 or IL-15, however, IL-18 promotes production of the Th2 cytokines IL-4 and IL-13 by CD4+ T cells and basophils.
Synonym Ig; Il-; Igif; Il-18; IL18
Expressed Host E. coli
Tag N-6×His
Swiss-Prot P70380
Gene ID 16173
Storage Store the lyophilized protein at -20°C to -80 °C for long term.
After reconstitution, the protein solution is stable at -20 °C for 3 months, at 2-8 °C for up to 1 week.
Reconstitution Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water.

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Antibodies (1)

Proteins (1)

* For research use only. Not for therapeutic or diagnostic purposes.

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