Product Type > Proteins

Recombinant Mouse 2B4/SLAMF4/CD244 Protein (RP00760)

Datasheet

Overview

Product name Recombinant Mouse 2B4/SLAMF4/CD244 Protein
Catalog No. RP00760
Description Recombinant Mouse 2B4/SLAMF4/CD244 Protein is produced by Human cells expression system. The target protein is expressed with sequence (Gln20-Asn221) of mouse 2B4/SLAMF4/CD244 (Accession #Q07763) fused with a 6×His tag at the C-terminus.
Purity > 95% by SDS-PAGE.
Endotoxin < 1 EU/μg of the protein by LAL method.
Formulation Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.Contact us for customized product form or formulation.
Species Mouse
Natural killer cell receptor 2B4 (2B4/CD244)is a 66 kDa type I transmembrane glycoprotein in the SLAMsubgroup of the CD2 protein family. SLAM family proteins have an extracellular domain (ECD) with two or fourIg-like domains and at least two cytoplasmic immunoreceptor tyrosine-based switch motifs (ITSMs). 2B4interacts with CD48, while other SLAM family proteins interact in a homophilic manner. The mouse 2B4 cDNAencodes a 397 amino acid (aa) precursor that includes a 19 aa signal sequence, a 207 aa ECD with one Ig-like V-type and one C2-type Ig-like domain, a 21 aa transmembrane segment, and a 150 aa cytoplasmic domain withfour ITSMs. Within the ECD, mouse 2B4 shares 46% and 68% aa sequence identity with human and rat 2B4, respectively. 2B4/CD48 signaling cooperates with other receptor systems to either promote or inhibit NK andCD8+ T cell activation. The inhibitory activities are distinct from those of MHC I restricted inhibitory NK cellreceptors. Ligation of 2B4 with antibodies or CD48 constructs can directly trigger inhibitory signaling or disruptan inhibitory interaction, leading to cellular activation. 2B4 can also induce signaling through CD48.
Synonym Natural killer cell receptor 2B4; NK cell type I receptor protein 2B4; NKR2B4; SLAM familymember 4; SLAMF4; Signaling lymphocytic activation molecule 4; CD244
Expressed Host HEK293 cells
Tag C-6×His
Swiss-Prot Q07763
Gene ID 18106
Storage Store the lyophilized protein at -20°C to -80 °C for long term.
After reconstitution, the protein solution is stable at -20 °C for 3 months, at 2-8 °C for up to 1 week.
Reconstitution Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water.

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