Product Type > Proteins

Recombinant Marmoset TIM-3/HAVCR2 Protein (RP00712)

Datasheet

Overview

Product name Recombinant Marmoset TIM-3/HAVCR2 Protein
Catalog No. RP00712
Description Recombinant Marmoset TIM-3/HAVCR2 Protein is produced by Human Cells expression system. The target protein is expressed with sequence (Glu24-Ile193) of marmoset TIM-3/HAVCR2 (Accession #F7I881) fused with a 6×His tag at the C-terminus.
Purity > 95% by SDS-PAGE.
Endotoxin < 1 EU/μg of the protein by LAL method.
Formulation Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.Contact us for customized product form or formulation.
Species Marmoset
T cell immunoglobulin and mucin domain-3 (TIM3, HAVCR2), is a transmembrane glycoprotein of the TIMfamily of immune regulating molecules and plays an important role in the Th1-mediated immune response.TIM3 is expressed on the Th1 cells, CD8 T-cells, monocytes, and dendritic cells, but not on Th2 cells. TIM3expressed by monocytes and dendritic cells facilitates phagocytosis of apoptotic cells and up-regulates cross-presentation of apoptotic cell-associated antigens through interaction with phosphatidylserine. Engagement ofTIM3 by its ligand galectin-9 induces a range of immunosuppressive functions which enhance immunetolerance and inhibit anti-tumor immunity. Stimulation of TIM3 with an agonistic antibody promotesinflammation through the activation of innate immune cells. TIM3 is also regarded as a potential targetmolecule for immunotherapy. TIM3 and programmed cell death 1 (PD-1) as two important coinhibitoryregulators of T cell responses, have been implicated with the T-cell dysfunction or exhaustion associated withchronic HBV infection including HBV-related HCC.
Synonym Hepatitis A virus cellular receptor 2 homolog; HAVcr-2; T-cell immunoglobulin and mucin domain-containing protein 3; T-cell immunoglobulin mucin receptor 3; T-cell membrane protein 3; Tim3; Timd3
Expressed Host HEK293 cells
Tag C-6×His
Swiss-Prot F7I881
Storage Store the lyophilized protein at -20°C to -80 °C for long term.
After reconstitution, the protein solution is stable at -20 °C for 3 months, at 2-8 °C for up to 1 week.
Reconstitution Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water.

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