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Recombinant Human VEGFA 121 Protein (RP00017)

Datasheet

Overview

Product nameRecombinant Human VEGFA 121 Protein
Catalog No.RP00017
DescriptionRecombinant Human VEGFA 121 Protein is produced by E. coli expression system. The target protein is expressed with sequence (Ala207-Arg327 (Lys321Asn)) of human VEGFA 121 (Accession #NP_001020541.2).
Bio-ActivityMeasured in a cell proliferation assay using HUVEC human umbilical vein endothelial cells. The ED50 for this effect is 1-6 ng/mL. The specific activity of recombinant human VEGF165 is approximately 1.7 x 103 U/μg, which is calibrated against recombinant human VEGF165 WHO Standard.
Swiss portP156922
Gene ID7422
SpeciesHuman
This protein is a member of the PDGF/VEGF growth factor family. It encodes a heparin-binding protein, which exists as a disulfide-linked homodimer. This growth factor induces proliferation and migration of vascular endothelial cells, and is essential for both physiological and pathological angiogenesis. Disruption of this gene in mice resulted in abnormal embryonic blood vessel formation. This protein is upregulated in many known tumors and its expression is correlated with tumor stage and progression. Elevated levels of this protein are found in patients with POEMS syndrome, also known as Crow-Fukase syndrome.
SynonymMVCD1; VEGF; VPF
Expressed HostE. coli
TagNo tag
Purity> 97% by SDS-PAGE.
Endotoxin< 1.0 EU/μg of the protein by LAL method.
FormulationLyophilized from a 0.22 μm filtered solution of 20 mM Tris, 100mM NaCl, pH 8.0.
StorageStore the lyophilized protein at -20°C to -80 °C for long term.
After reconstitution, the protein solution is stable at -20 °C for 3 months, at 2-8 °C for up to 1 week.
ReconstitutionReconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water.

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