Product Type > Proteins

Recombinant Human TNFRSF10D/TRAIL R4 Protein (RP00814)

Datasheet

Overview

Product name Recombinant Human TNFRSF10D/TRAIL R4 Protein
Catalog No. RP00814
Description Recombinant Human TNFRSF10D/TRAIL R4 Protein is produced by Human Cells expression system. The target protein is expressed with sequence (Ala56-His211) of human TNFRSF10D/TRAIL R4 (Accession #Q9UBN6) fused with an Fc tag at the C-terminus.
Purity > 95% by SDS-PAGE.
Endotoxin < 1 EU/μg of the protein by LAL method.
Formulation Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.Contact us for customized product form or formulation.
Species Human
Human TRAIL R4 is a type 1, TNF R family membrane protein, which is a receptor for TRAIL (APO2 ligand). TRAILR4 contains an extracellular TRAIL-binding domain, a transmembrane domain, and a truncated cytoplasmicdeath domain. In the new TNF superfamily nomenclature, TRAIL R4 is referred to as TNFRSF10D. TRAIL R4 isunique among the TRAIL receptors in that its cytoplasmic domain contains a truncated consensus deathdomain motif. Binding of TRAIL R4 does not result in an apoptotic signal. Overexpression of TRAIL R4 canprotect cells bearing TRAIL R1 and/or TRAIL R2 from TRAIL mediated apoptosis. The human soluble TRAIL R4/Fcchimera neutralizes the ability of TRAIL to induce apoptosis.
Synonym CD264; DCR2; TRAIL-R4; TRAILR4; TRUNDD; TNFRSF10D; DCR2; TRAIL-R4; TRAILR4; TRUNDD
Expressed Host HEK293 cells
Tag C-Fc
Swiss-Prot Q9UBN6
Gene ID 8793
Storage Store the lyophilized protein at -20°C to -80 °C for long term.
After reconstitution, the protein solution is stable at -20 °C for 3 months, at 2-8 °C for up to 1 week.
Reconstitution Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water.

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