Product Type > Proteins

Recombinant Human TNF-alpha/TNFα/TNFSF2 Protein (RP00475)

Datasheet

Overview

Product name Recombinant Human TNF-alpha/TNFα/TNFSF2 Protein
Catalog No. RP00475
Description Recombinant Human TNF-alpha/TNFα/TNFSF2 Protein is produced by E. coli expression system. The target protein is expressed with sequence (Val77-Leu233) of human TNF-alpha/TNFα/TNFSF2 (Accession #P01375) fused with an initial Met at the N-terminus.
Purity > 95% by SDS-PAGE.
Endotoxin < 1 EU/μg of the protein by LAL method.
Formulation Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.0.Contact us for customized product form or formulation.
Species Human
TNF α is a homotrimer with a subunit molecular mass of 17 kD cytokine that binds to TNFRSF1A/TNFR1 andTNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. Itplays a major role in growth regulation, differentiation, inflammation, viral replication, tumorigenesis, autoimmune diseases and in viral, bacterial, fungal, and parasitic infections. Besides inducing hemorrhagicnecrosis of tumors, TNF was found to be involved in tumorigenesis, tumor metastasis, viral replication, septicshock, fever, inflammation, and autoimmune diseases including Crohn ’ s disease, and rheumatoid arthritis aswell as graft-versus-host disease.
Synonym TNF; DIF; TNF-alpha; TNFA; TNFSF2; TNLG1F; tumor necrosis factor; TNF-α; DIF; TNF-alpha; TNFA; TNFSF2; TNLG1F; TNF alpha
Expressed Host E. coli
Tag No tag
Swiss-Prot P01375
Gene ID 7124
Storage Store the lyophilized protein at -20°C to -80 °C for long term.
After reconstitution, the protein solution is stable at -20 °C for 3 months, at 2-8 °C for up to 1 week.
Reconstitution Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water.

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