Product Type > Proteins

Recombinant Human TIGIT/VSIG9/VSTM3 Protein (RP00783)

Datasheet

Overview

Product name Recombinant Human TIGIT/VSIG9/VSTM3 Protein
Catalog No. RP00783
Description Recombinant Human TIGIT/VSIG9/VSTM3 Protein is produced by Human Cells expression system. The target protein is expressed with sequence (Met22-Pro141) of human TIGIT/VSIG9/VSTM3 (Accession #Q495A1) fused with an Fc tag at the C-terminus.
Bio-Activity Measured by its binding ability in a functional ELISA. When Recombinant Human CD155/PVR is coated at 2.5 μg/mL (100 μL/well), the concentration of Recombinant Human TIGIT Fc Chimera that produces 50% optimal binding response is 40-200 ng/mL.
Purity > 95% by SDS-PAGE.
Endotoxin < 1 EU/μg of the protein by LAL method.
Formulation Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.Contact us for customized product form or formulation.
Species Human
T cell immunoreceptor with Ig and ITIM domains (TIGIT) is a member of the CD28 family within the Igsuperfamily of proteins. TIGIT is expressed on NK cells and subsets of activated, memory and regulatory T cells, and particularly on follicular helper T cells within secondary lymphoid organs. It binds to CD155 and Nectin-2that appear on dendritic cells (DC) and endothelium. Ligation of TIGIT on T cells down-regulates TCR-mediatedactivation and subsequent proliferation, while NK cell TIGIT ligation blocks NK cell cytotoxicity. Through CD155and Nectin-2, which also interact with DNAM-1/CD226 and CD96/Tactile, TIGIT is part of an interactingnetwork of Ig superfamily members that may augment or oppose each other. In particular, TIGIT binding toCD155 can antagonize the effects of DNAM1.
Synonym VSIG9; VSTM3; WUCAM; TIGIT
Expressed Host HEK293 cells
Tag C-Fc
Swiss-Prot Q495A1
Gene ID 201633
Storage Store the lyophilized protein at -20°C to -80 °C for long term.
After reconstitution, the protein solution is stable at -20 °C for 3 months, at 2-8 °C for up to 1 week.
Reconstitution Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water.

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Proteins (2)

Antibodies (3)

* For research use only. Not for therapeutic or diagnostic purposes.

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