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Recombinant Human PD-L1/B7-H1 Protein (RP00068)

Datasheet

Overview

Product nameRecombinant Human PD-L1/B7-H1 Protein
Catalog No.RP00068
DescriptionRecombinant Human PD-L1/B7-H1 Protein is produced by HEK293 expression system. The target protein is expressed with sequence (Phe19-Thr239) of human PD-L1/B7-H1 (Accession #NP_054862.1) fused with a 6×His tag at the C-terminus.
Swiss portQ9NZQ7
Gene ID29126
SpeciesHuman
This protein is an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation.
SynonymB7-H; B7H1; PD-L1; PDCD1L1; PDCD1LG1; PDL1
Expressed HostHEK293 cells
Tag6×His tag at the C-terminus
Purity> 97% by SDS-PAGE.
Endotoxin< 0.1 EU/μg of the protein by LAL method.
FormulationLyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.
StorageStore the lyophilized protein at -20°C to -80 °C for long term.
After reconstitution, the protein solution is stable at -20 °C for 3 months, at 2-8 °C for up to 1 week.
ReconstitutionReconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water.

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