Product Type > Proteins

Recombinant Human IL-28A/IFN-λ2 Protein (RP00767)

Datasheet

Overview

Product name Recombinant Human IL-28A/IFN-λ2 Protein
Catalog No. RP00767
Description Recombinant Human IL-28A/IFN-λ2 Protein is produced by Human cells expression system. The target protein is expressed with sequence (Val26-Val200) of human IL-28A/IFN-λ2 (Accession #Q8IZJ0) fused with a 6×His tag at the C-terminus.
Purity > 95% by SDS-PAGE.
Endotoxin < 1 EU/μg of the protein by LAL method.
Formulation Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.Contact us for customized product form or formulation.
Species Human
IL-28A (Interferon- λ 2; IFN- λ 2), IL-28B/IFN- λ 3, and IL-29/IFN- λ 1 are type III interferons which are distantlyrelated to IL-10 family and type I IFN family cytokines. Mature human IL-28A is an approximately 22-25 kDaprotein that shares 66% amino acid (aa) sequence identity with mouse and rat IL-28A and shows cross-speciesactivity. It shares 96% and 70% aa sequence identity with human IL-28B and IL-29, respectively. IL-28Apromotes the Th1 polarization of dendritic cells in the airway and inhibits Th2 and Th17 mediatedinflammation. IL-28A additionally exhibits anti-tumor activity, in part by enhancing IL-12 dependent anti-tumorCTL responses in vivo. In contrast, it is up-regulated in invasive bladder cancer where it promotes tumor cellmigration.
Synonym IFNL2; IL-28A; IL28A; IFNL2a; IFNL3a; IL-28A
Expressed Host HEK293 cells
Tag C-6×His
Swiss-Prot Q8IZJ0
Gene ID 282616
Storage Store the lyophilized protein at -20°C to -80 °C for long term.
After reconstitution, the protein solution is stable at -20 °C for 3 months, at 2-8 °C for up to 1 week.
Reconstitution Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water.

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