Product Type > Proteins

Recombinant Human HMGB1/HMG-1 Protein (RP00515)

Datasheet

Overview

Product name Recombinant Human HMGB1/HMG-1 Protein
Catalog No. RP00515
Description Recombinant Human HMGB1/HMG-1 Protein is produced by Human cells expression system. The target protein is expressed with sequence (Gly2-Glu215) of human HMGB1/HMG-1 (Accession #P09429) fused with a 6×His tag at the C-terminus.
Purity > 95% by SDS-PAGE.
Endotoxin < 1 EU/μg of the protein by LAL method.
Formulation Lyophilized from a 0.2 μm filtered solution of 20mM TrisHCl, 150mM NaCl, pH 8.0.Contact us for customized product form or formulation.
Species Human
High mobility group protein B1 is a member of the HMGB family consisting of three members, HMGB1, HMGB2and HMGB3.It Contains 2 HMG box DNA-binding domains entitled box A and box B and It is a highly negative-charged C terminus. As a nuclear protein, HMGB1 stabilizes nucleosomes and allows bending of DNA thatfacilitates gene transcription which is essential for individual survival. Meanwhile, it is revealed that HMGB1can also act as a cytokine extracellularlly and regulates monocyte, T cell, dendritic cell activities in inflammatoryresponses.
Synonym HMG-1; HMG1; HMG3; SBP-1; HMGB1
Expressed Host HEK293 cells
Tag C-6×His
Swiss-Prot P09429
Gene ID 3146
Storage Store the lyophilized protein at -20°C to -80 °C for long term.
After reconstitution, the protein solution is stable at -20 °C for 3 months, at 2-8 °C for up to 1 week.
Reconstitution Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water.

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* For research use only. Not for therapeutic or diagnostic purposes.

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