Overview
Product name |
Recombinant Human Fc epsilon RII/CD23 Protein |
Catalog No. |
RP00770 |
Description |
Recombinant Human Fc epsilon RII/CD23 Protein is produced by Human cells expression system. The target protein is expressed with sequence (Asp48-Ser321) of human Fc epsilon RII/CD23 (Accession #P06734) fused with an 8×His tag at the N-terminus. |
Purity |
> 95% by SDS-PAGE. |
Endotoxin |
< 1 EU/μg of the protein by LAL method. |
Formulation |
Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.Contact us for customized product form or formulation. |
Species |
Human |
Background
Low affinity immunoglobulin epsilon Fc receptor(CD23) is a secreted and single-pass type II membrane proteinwhich is also exists as a soluble excreted form. There are two forms of CD23: CD23a and CD23b. CD23a ispresent on follicular B cells, whereas CD23b requires IL-4 to be expressed on T-cells, monocytes, Langerhanscells, eosinophils, and macrophages. Unlike many of the antibody receptors, CD23/FCER2 is a C-type lectin. It isfound on mature B cells, activated macrophages, eosinophils, follicular dendritic cells, and platelets. In flowcytometry, CD23/FCER2 is helpful in the differentiation of chronic lymphocytic leukemia (CD23-positive) frommantle cell leukemia (CD23-negative). CD23/FCER2 can also be demonstrated in germinal centre B-cells usingimmunohistochemistry, but it is not present in the resting cells of the surrounding mantle zone. CD23/FCER2has essential roles in the regulation of IgE production and in the differentiation of B-cells (it is a B-cell-specificantigen).
Product information
Synonym |
BLAST-2; CD23; CD23A; CLEC4J; FCE2; IGEBF; FCER2; BLAST-2; Fc fragment of IgE receptor II; CD23; CD23A; CLEC4J; FCE2; IGEBF |
Expressed Host |
HEK293 cells |
Tag |
N-8×His |
Swiss-Prot |
P06734 |
Gene ID |
2208 |
Usage guide
Storage |
Store the lyophilized protein at -20°C to -80 °C for long term. After reconstitution, the protein solution is stable at -20 °C for 3 months, at 2-8 °C for up to 1 week. |
Reconstitution |
Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. |
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* For research use only. Not for therapeutic or diagnostic
purposes.