Product Type > Proteins

Recombinant Human Chemerin/Retinoic acid receptor responder protein 2 Protein (RP00643)

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Overview

Product name Recombinant Human Chemerin/Retinoic acid receptor responder protein 2 Protein
Catalog No. RP00643
Description Recombinant Human Chemerin/Retinoic acid receptor responder protein 2 Protein is produced by Human cells expression system. The target protein is expressed with sequence (Glu21-Ser157) of human Chemerin/Retinoic acid receptor responder protein 2 (Accession #Q99969) fused with a 6×His tag at the C-terminus.
Bio-Activity Measured by its ability to chemoattract BaF3 mouse pro-B cells transfected with human ChemR23. The ED50 for this effect is 4-20 ng/mL.
Purity > 95% by SDS-PAGE.
Endotoxin < 1 EU/μg of the protein by LAL method.
Formulation Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH7.4.Contact us for customized product form or formulation.
Species Human
Retinoic acid receptor responder protein 2(RARRES2) is a secreted protein that in humans is encoded by theRARRES2 gene. It is highly expressed in skin, also found in pancreas, liver, spleen, prostate, ovary, smallintestine and colon. It is a chemoattractant protein that acts as a ligand for the G protein-coupled receptorCMKLR1. RARRES2 is secreted in an inactive form as prochemerin and is activated through cleavage of the C-terminus by inflammatory and coagulation serine proteases. It is thought to act as a cell surface receptor, found to stimulate chemotaxis of dendritic cells and macrophages to the site of inflammation. RARRES2 isinhibited in psoriatic lesions, it is activated by tazarotene in skin rafts and in the epidermis of psoriatic lesions.
Synonym RARRES2; HP10433; TIG2
Expressed Host HEK293 cells
Tag C-6×His
Swiss-Prot Q99969
Gene ID 5919
Storage Store the lyophilized protein at -20°C to -80 °C for long term.
After reconstitution, the protein solution is stable at -20 °C for 3 months, at 2-8 °C for up to 1 week.
Reconstitution Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water.

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* For research use only. Not for therapeutic or diagnostic purposes.

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