Product Type > Antibodies > Primary Antibodies > Monoclonal Antibodies

VAV1 Mouse mAb (A0770)

Datasheet SDS

Tested applications: WB IHC-P IF/ICC IP ChIP ChIP-seq RIP FC FC(Intra) ELISA MeDIP Nucleotide Array DB FACS CoIP FCM CUT&Tag meRIP Inhibition

Reactivity:Human

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Overview

Product name VAV1 Mouse mAb
Catalog No. A0770
Host species Mouse
Purification method Affinity purification
Isotype IgG

Background

This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. The encoded protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. The encoded protein has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Immunogen information

Immunogen Recombinant protein of human VAV1
Sequence Email for sequence
Gene ID 7409
Swiss prot P15498
Synonyms VAV; VAV1
Calculated MW 98kDa
Observed MW 105kDa

Applications

Reactivity Human
Tested applications WB IHC-P IF/ICC IP ChIP ChIP-seq RIP FC FC(Intra) ELISA MeDIP Nucleotide Array DB FACS CoIP FCM CUT&Tag meRIP Inhibition
Recommended dilution
  • WB 1:500 - 1:2000
Storage buffer Store at 4℃. Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide, pH7.3.
Application key Western blotting    
Positive samples Raji, Jurkat, K-562
Cellular location cell-cell junction, cytoplasm, cytosol, plasma membrane

Research Area

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Related Targets

Based on existing publications, the following genes are closely related to research on VAV1. (Numbers indicate number of published articles where both targets appear.)

1/

Related Research Area

Based on existing publications, the following research topics are related to VAV1. (Distance between topics and target gene indicate popularity.) VAV1

* Data provided by citexs.com, for reference only.

Publishing research using A0770? Please let us know so that we can cite the reference in this datasheet.

* For research use only. Not for therapeutic or diagnostic purposes.

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