Product Type > Antibodies > Primary Antibodies > Phospho-specific Antibodies

Phospho-TP53BP1-T543 Rabbit pAb (AP0861)

Datasheet

Tested applications: WB IHC-P IF/ICC IP ChIP ChIP-seq RIP FC FC(Intra) ELISA MeDIP Nucleotide Array DB FACS CoIP FCM CUT&Tag meRIP Inhibition

Reactivity:Human

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Overview

Product name Phospho-TP53BP1-T543 Rabbit pAb
Catalog No. AP0861
Host species Rabbit
Purification method Affinity purification
Isotype IgG

Background

This gene encodes a protein that functions in the DNA double-strand break repair pathway choice, promoting non-homologous end joining (NHEJ) pathways, and limiting homologous recombination. This protein plays multiple roles in the DNA damage response, including promoting checkpoint signaling following DNA damage, acting as a scaffold for recruitment of DNA damage response proteins to damaged chromatin, and promoting NHEJ pathways by limiting end resection following a double-strand break. These roles are also important during V(D)J recombination, class switch recombination and at unprotected telomeres. Alternative splicing results in multiple transcript variants encoding different isoforms.

Immunogen information

Immunogen A synthetic phosphorylated peptide around T543 of human TP53BP1 (NP_001135451.1).
Sequence IDEDG
Gene ID 7158
Swiss prot Q12888
Synonyms p202; 53BP1; TDRD30; p53BP1; Phospho-TP53BP1-T543
Calculated MW 214kDa
Observed MW Refer to figures

Applications

Reactivity Human
Tested applications WB IHC-P IF/ICC IP ChIP ChIP-seq RIP FC FC(Intra) ELISA MeDIP Nucleotide Array DB FACS CoIP FCM CUT&Tag meRIP Inhibition
Recommended dilution
  • WB 1:500 - 1:2000
Storage buffer Store at -20℃. Avoid freeze / thaw cycles.
Buffer: PBS with 0.01% thimerosal, 50% glycerol, pH7.3.
Application key Western blotting    
Positive samples
Cellular location Chromosome, Nucleus, centromere, kinetochore

Research Area

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Related Targets

Based on existing publications, the following genes are closely related to research on TP53BP1. (Numbers indicate number of published articles where both targets appear.)

1/

Related Research Area

Based on existing publications, the following research topics are related to TP53BP1. (Distance between topics and target gene indicate popularity.) TP53BP1

* Data provided by citexs.com, for reference only.

Publishing research using AP0861? Please let us know so that we can cite the reference in this datasheet.

Antibodies (3)

Secondary Antibodies (23)

* For research use only. Not for therapeutic or diagnostic purposes.

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