Product Type > Antibodies > Primary Antibodies > Phospho-specific Antibodies

Phospho-INSR-Y1146 + IGF1R-Y1131 Rabbit pAb (AP0583)

Datasheet SDS

Tested applications: WB IHC-P IF/ICC IP ChIP ChIP-seq RIP FC FC(Intra) ELISA MeDIP Nucleotide Array DB FACS CoIP FCM CUT&Tag meRIP Inhibition

Reactivity:Human

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Overview

Product name Phospho-INSR-Y1146 + IGF1R-Y1131 Rabbit pAb
Catalog No. AP0583
Host species Rabbit
Purification method Affinity purification
Isotype IgG

Background

This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

Immunogen information

Immunogen A phospho specific peptide corresponding to residues surrounding Y1131 of human IGF1R
Sequence Email for sequence
Gene ID 3480
Swiss prot P08069
Synonyms IGFR; CD221; IGFIR; JTK13; Phospho-INSR-Y1146 + IGF1R-Y1131
Calculated MW 155kDa
Observed MW Refer to figures

Applications

Reactivity Human
Tested applications WB IHC-P IF/ICC IP ChIP ChIP-seq RIP FC FC(Intra) ELISA MeDIP Nucleotide Array DB FACS CoIP FCM CUT&Tag meRIP Inhibition
Recommended dilution
  • WB 1:500 - 1:2000
Storage buffer Store at -20℃. Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Application key Western blotting    
Positive samples
Cellular location Cell membrane, Single-pass type I membrane protein

Research Area

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Related Targets

Based on existing publications, the following genes are closely related to research on IGF1R. (Numbers indicate number of published articles where both targets appear.)

1/

Related Research Area

Based on existing publications, the following research topics are related to IGF1R. (Distance between topics and target gene indicate popularity.) IGF1R

* Data provided by citexs.com, for reference only.

Publishing research using AP0583? Please let us know so that we can cite the reference in this datasheet.

Antibodies (6)

ELISA Kits (1)

Proteins (3)

Secondary Antibodies (23)

* For research use only. Not for therapeutic or diagnostic purposes.

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