Product Type > Antibodies > Primary Antibodies > Phospho-specific Antibodies

Phospho-AKT1-S473 Rabbit pAb (AP0140)

Reviews (4) Publications (108) Datasheet SDS

Tested applications: WB IHC-P IF/ICC IP ChIP ChIP-seq RIP FC FC(Intra) ELISA MeDIP Nucleotide Array DB FACS CoIP FCM CUT&Tag meRIP Inhibition

Reactivity:Human, Mouse, Rat

ABclonal:Western blot - Phospho-AKT1-S473 Rabbit pAb (AP0140)

Western blot analysis of extracts of Jurka cells, using Phospho-AKT1-S473 antibody (AP0140) at 1:1000 dilution.Jurkat cells were treated by Serum-starvation overnight at 37℃.Jurkat cells were treated by Calyculin A (100 nM) at 37℃ for 30 minutes after serum-starvation overnight.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.
Lysates/proteins: 25μg per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit (RM00020).
Exposure time: 1s.

Western blot analysis of extracts of C6 cells, using Phospho-AKT1-S473 antibody (AP0140) at 1:1000 dilution.C6 cells were treated by Serum-starvation overnight at 37℃.C6 cells were treated by Calyculin A (100 nM) at 37℃ for 30 minutes after serum-starvation overnight.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.
Lysates/proteins: 25μg per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Enhanced Kit (RM00021).
Exposure time: 10s.

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Overview

Product name	Phospho-AKT1-S473 Rabbit pAb
Catalog No.	AP0140
Host species	Rabbit
Purification method	Affinity purification
Isotype	IgG

Background

This gene encodes one of the three members of the human AKT serine-threonine protein kinase family which are often referred to as protein kinase B alpha, beta, and gamma. These highly similar AKT proteins all have an N-terminal pleckstrin homology domain, a serine/threonine-specific kinase domain and a C-terminal regulatory domain. These proteins are phosphorylated by phosphoinositide 3-kinase (PI3K). AKT/PI3K forms a key component of many signalling pathways that involve the binding of membrane-bound ligands such as receptor tyrosine kinases, G-protein coupled receptors, and integrin-linked kinase. These AKT proteins therefore regulate a wide variety of cellular functions including cell proliferation, survival, metabolism, and angiogenesis in both normal and malignant cells. AKT proteins are recruited to the cell membrane by phosphatidylinositol 3, 4, 5-trisphosphate (PIP3) after phosphorylation of phosphatidylinositol 4, 5-bisphosphate (PIP2) by PI3K. Subsequent phosphorylation of both threonine residue 308 and serine residue 473 is required for full activation of the AKT1 protein encoded by this gene. Phosphorylation of additional residues also occurs, for example, in response to insulin growth factor-1 and epidermal growth factor. Protein phosphatases act as negative regulators of AKT proteins by dephosphorylating AKT or PIP3. The PI3K/AKT signalling pathway is crucial for tumor cell survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating AKT1 which then phosphorylates and inactivates components of the apoptotic machinery. AKT proteins also participate in the mammalian target of rapamycin (mTOR) signalling pathway which controls the assembly of the eukaryotic translation initiation factor 4F (eIF4E) complex and this pathway, in addition to responding to extracellular signals from growth factors and cytokines, is disregulated in many cancers. Mutations in this gene are associated with multiple types of cancer and excessive tissue growth including Proteus syndrome and Cowden syndrome 6, and breast, colorectal, and ovarian cancers. Multiple alternatively spliced transcript variants have been found for this gene.

Immunogen information

Immunogen	A synthetic phosphorylated peptide around S473 of human Akt1 (NP_005154.2).
Sequence	QFSYS
Gene ID	207
Swiss prot	P31749
Synonyms	AKT; PKB; RAC; PRKBA; PKB-ALPHA; RAC-ALPHA; Phospho-AKT1-S473
Calculated MW	56kDa
Observed MW	60kDa

Applications

Reactivity	Human, Mouse, Rat
Tested applications	WB IHC-P IF/ICC IP ChIP ChIP-seq RIP FC FC(Intra) ELISA MeDIP Nucleotide Array DB FACS CoIP FCM CUT&Tag meRIP Inhibition
Recommended dilution	WB 1:500 - 1:1000
Storage buffer	Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Application key	Western blotting
Positive samples	Jurkat, C6
Cellular location	Cell membrane, Cytoplasm, Nucleus
Customer validation	WB (Human chronic myeloid leukemia cells, C57BL6, 293T, 3T3-L1, Mus musculus, Homo sapiens, Rattus norvegicus, Danio rerio, Dendrobium officinale Kimura et Migo, Bovine, Capra hircus, Apocynum venetum leaf, Mannan Oligosaccharide, Gallus gallus, Sus scrofa) IHC (Mus musculus, Rattus norvegicus) IF (Rattus norvegicus) IHC (Homo sapiens,Mus musculus) IF/ICC (Homo sapiens,Mus musculus) IF (Rattus norvegicus) IF (Homo sapiens, Rattus norvegicus) WB (Rattus norvegicus) WB，IHC，IF (Homo sapiens)

Research Area

Phospho-AKT1-S473 Rabbit pAb images

Western blot - Phospho-AKT1-S473 Rabbit pAb (AP0140)

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Related Targets

Based on existing publications, the following genes are closely related to research on AKT1. (Numbers indicate number of published articles where both targets appear.)

◀1/▶

Related Research Area

Based on existing publications, the following research topics are related to AKT1. (Distance between topics and target gene indicate popularity.) AKT1

* Data provided by citexs.com, for reference only.

References for Phospho-AKT1-S473 Rabbit pAb (AP0140)

Product:

Phospho-AKT1-S473 Rabbit pAb

Journal:

Toxicological sciences

Application:

WB, IHC

IF:

4.849

Species:

Mus musculus

PMID:

26089345

Title:

Phosphatidylinositol 3-Kinase Mediates β-Catenin Dysfunction of Airway Epithelium in a Toluene Diisocyanate-Induced Murine Asthma Model

References for Phospho-AKT1-S473 Rabbit pAb (AP0140)

Product:

Phospho-AKT1-S473 Rabbit pAb

Journal:

Frontiers in immunology

Application:

IF:

7.561

Species:

Mus musculus

PMID:

28321214

Title:

Exogenous l-Valine Promotes Phagocytosis to Kill Multidrug-Resistant Bacterial Pathogens

References for Phospho-AKT1-S473 Rabbit pAb (AP0140)

Product:

Phospho-AKT1-S473 Rabbit pAb

Journal:

Cell death & disease

Application:

IF:

8.469

Species:

Homo sapiens

PMID:

28151472

Title:

CALCB splice region pathogenic variants leading to plasma cell neurotropic enrichment in type 1 autoimmune pancreatitis

References for Phospho-AKT1-S473 Rabbit pAb (AP0140)

Product:

Phospho-AKT1-S473 Rabbit pAb

Journal:

Oncotarget

Application:

IF:

3.765

Species:

Homo sapiens

PMID:

29190957

Title:

MicroRNA-30c-5p ameliorates hypoxia-reoxygenation-induced tubular epithelial cell injury via HIF1α stabilization by targeting SOCS3

References for Phospho-AKT1-S473 Rabbit pAb (AP0140)

Product:

Phospho-AKT1-S473 Rabbit pAb

Journal:

Biochemical And Biophysical Research Communications

Application:

IF:

3.575

Species:

Homo sapiens

PMID:

29137981

Title:

Umbilical cord-derived mesenchymal stem cells alleviated inflammation and inhibited apoptosis in interstitial cystitis via AKT/mTOR signaling pathway

References for Phospho-AKT1-S473 Rabbit pAb (AP0140)

Product:

Phospho-AKT1-S473 Rabbit pAb

Journal:

BioMed Research International

Application:

IF:

3.411

Species:

Homo sapiens

PMID:

29750154

Title:

Ginsenoside Rg3 Suppresses Proliferation and Induces Apoptosis in Human Osteosarcoma

References for Phospho-AKT1-S473 Rabbit pAb (AP0140)

Product:

Phospho-AKT1-S473 Rabbit pAb

Journal:

Journal of Natural Medicines

Application:

IF:

2.343

Species:

Mus musculus

PMID:

29740735

Title:

Dandelion root extract protects NCM460 colonic cells and relieves experimental mouse colitis

References for Phospho-AKT1-S473 Rabbit pAb (AP0140)

Product:

Phospho-AKT1-S473 Rabbit pAb

Journal:

OncoTargets and therapy

Application:

IF:

4.147

Species:

Homo sapiens

PMID:

29785118

Title:

Traditional Chinese medicine Astragalus polysaccharide enhanced antitumor effects of the angiogenesis inhibitor apatinib in pancreatic cancer cells on proliferation, invasiveness, and apoptosis

References for Phospho-AKT1-S473 Rabbit pAb (AP0140)

Product:

Phospho-AKT1-S473 Rabbit pAb

Journal:

International journal of biological macromolecules

Application:

IF:

6.953

Species:

Rattus norvegicus

PMID:

30391592

Title:

CXCL12 has therapeutic value in facial nerve injury and promotes Schwann cells autophagy and migration via PI3K-AKT-mTOR signal pathway.

References for Phospho-AKT1-S473 Rabbit pAb (AP0140)

Product:

Phospho-AKT1-S473 Rabbit pAb

Journal:

International journal of biological macromolecules

Application:

IF:

6.953

Species:

Danio rerio

PMID:

30414415

Title:

Anti-melanogenesis of novel kojic acid derivatives in B16F10 cells and zebrafish.

References for Phospho-AKT1-S473 Rabbit pAb (AP0140)

Product:

Phospho-AKT1-S473 Rabbit pAb

Journal:

Journal of cellular biochemistry

Application:

IF:

4.429

Species:

Homo sapiens

PMID:

30450569

Title:

Long noncoding RNA STXBP5-AS1 inhibits cell proliferation, migration, and invasion via preventing the PI3K/AKT against STXBP5 expression in non-small-cell lung carcinoma.

References for Phospho-AKT1-S473 Rabbit pAb (AP0140)

Product:

Phospho-AKT1-S473 Rabbit pAb

Journal:

Cellular physiology and biochemistry

Application:

IF:

4.644

Species:

Homo sapiens

PMID:

30504711

Title:

Cr(VI)-Induced Autophagy Protects L-02 Hepatocytes from Apoptosis Through the ROS-AKT-mTOR Pathway.

References for Phospho-AKT1-S473 Rabbit pAb (AP0140)

Product:

Phospho-AKT1-S473 Rabbit pAb

Journal:

Cell death and differentiation

Application:

IF:

15.828

Species:

Mus musculus

PMID:

30683918

Title:

The role of the LncRNA-FA2H-2-MLKL pathway in atherosclerosis by regulation of autophagy flux and inflammation through mTOR-dependent signaling.

References for Phospho-AKT1-S473 Rabbit pAb (AP0140)

Product:

Phospho-AKT1-S473 Rabbit pAb

Journal:

OncoTargets and therapy

Application:

IF:

4.147

Species:

Homo sapiens

PMID:

30881044

Title:

Long noncoding RNA STXBP5-AS1 inhibits cell proliferation, migration, and invasion through inhibiting the PI3K/AKT signaling pathway in gastric cancer cells.

References for Phospho-AKT1-S473 Rabbit pAb (AP0140)

Product:

Phospho-AKT1-S473 Rabbit pAb

Journal:

Oncology letters

Application:

IF:

2.967

Species:

Homo sapiens

PMID:

31452769

Title:

Matrine induces apoptosis in acute myeloid leukemia cells by inhibiting the PI3K/Akt/mTOR signaling pathway.

References for Phospho-AKT1-S473 Rabbit pAb (AP0140)

Product:

Phospho-AKT1-S473 Rabbit pAb

Journal:

International immunopharmacology

Application:

IF:

4.932

Species:

Rattus norvegicus

PMID:

31466050

Title:

Genipin attenuates mitochondrial-dependent apoptosis, endoplasmic reticulum stress, and inflammation via the PI3K/AKT pathway in acute lung injury.

References for Phospho-AKT1-S473 Rabbit pAb (AP0140)

Product:

Phospho-AKT1-S473 Rabbit pAb

Journal:

Free radical biology & medicine

Application:

IF:

7.376

Species:

Homo sapiens,Mus musculus

PMID:

31560953

Title:

GL-V9 exerts anti-T cell malignancies effects via promoting lysosome-dependent AKT1 degradation and activating AKT1/FOXO3A/BIM axis.

References for Phospho-AKT1-S473 Rabbit pAb (AP0140)

Product:

Phospho-AKT1-S473 Rabbit pAb

Journal:

BMC Molecular Biology

Application:

IF:

2.946

Species:

Homo sapiens

PMID:

31703613

Title:

PSMD1 and PSMD2 regulate HepG2 cell proliferation and apoptosis via modulating cellular lipid droplet metabolism

References for Phospho-AKT1-S473 Rabbit pAb (AP0140)

Product:

Phospho-AKT1-S473 Rabbit pAb

Journal:

Frontiers in Oncology

Application:

IF:

6.244

Species:

Homo sapiens

PMID:

31355132

Title:

Human SP-D Acts as an Innate Immune Surveillance Molecule Against Androgen-Responsive and Androgen-Resistant Prostate Cancer Cells

References for Phospho-AKT1-S473 Rabbit pAb (AP0140)

Product:

Phospho-AKT1-S473 Rabbit pAb

Journal:

Life Sciences

Application:

IF:

5.037

Species:

Rattus norvegicus

PMID:

31991180

Title:

Schisantherin A causes endothelium-dependent and -independent vasorelaxation in isolated rat thoracic aorta

References for Phospho-AKT1-S473 Rabbit pAb (AP0140)

Product:

Phospho-AKT1-S473 Rabbit pAb

Journal:

Applied Microbiology and Biotechnology

Application:

IF:

4.813

Species:

Mus musculus

PMID:

32095863

Title:

Attenuated Salmonella engineered with an apoptosis-inducing factor (AIF) eukaryotic expressing system enhances its anti-tumor effect in melanoma in vitro and in vivo

References for Phospho-AKT1-S473 Rabbit pAb (AP0140)

Product:

Phospho-AKT1-S473 Rabbit pAb

Journal:

Cell Death & Disease

Application:

IF:

8.469

Species:

Mus musculus

PMID:

32108135

Title:

Nontoxic concentration of ochratoxin A decreases the dosage of cyclosporine A to induce chronic nephropathy model via autophagy mediated by toll-like receptor 4

References for Phospho-AKT1-S473 Rabbit pAb (AP0140)

Product:

Phospho-AKT1-S473 Rabbit pAb

Journal:

Inflammation

Application:

IF:

4.092

Species:

Homo sapiens

PMID:

32128658

Title:

GSTP1 Inhibits LPS-Induced Inflammatory Response Through Regulating Autophagy in THP-1 Cells

References for Phospho-AKT1-S473 Rabbit pAb (AP0140)

Product:

Phospho-AKT1-S473 Rabbit pAb

Journal:

Journal of Medicinal Food

Application:

IF:

2.786

Species:

Rattus norvegicus

PMID:

32181695

Title:

Schisandra Chinensis Acidic Polysaccharide Improves the Insulin Resistance in Type 2 Diabetic Rats by Inhibiting Inflammation

References for Phospho-AKT1-S473 Rabbit pAb (AP0140)

Product:

Phospho-AKT1-S473 Rabbit pAb

Journal:

International Journal of Molecular Sciences

Application:

IF:

5.923

Species:

Mus musculus

PMID:

32183046

Title:

Vaccarin Regulates Diabetic Chronic Wound Healing through FOXP2/AGGF1 Pathways

References for Phospho-AKT1-S473 Rabbit pAb (AP0140)

Product:

Phospho-AKT1-S473 Rabbit pAb

Journal:

Oncotargets and Therapy

Application:

IF:

4.147

Species:

Homo sapiens

PMID:

32346296

Title:

Lamin B1 Overexpresses in Lung Adenocarcinoma and Promotes Proliferation in Lung Cancer Cells via AKT Pathway

References for Phospho-AKT1-S473 Rabbit pAb (AP0140)

Product:

Phospho-AKT1-S473 Rabbit pAb

Journal:

International Journal of Oncology

Application:

IF:

5.65

Species:

Homo sapiens

PMID:

29048657

Title:

Toosendanin suppresses oncogenic phenotypes of human gastric carcinoma SGC?7901 cells partly via miR?200a?mediated downregulation of β-catenin pathway

References for Phospho-AKT1-S473 Rabbit pAb (AP0140)

Product:

Phospho-AKT1-S473 Rabbit pAb

Journal:

EBioMedicine

Application:

IF:

8.143

Species:

Mus musculus

PMID:

27333037

Title:

Enho Mutations Causing Low Adropin: A Possible Pathomechanism of MPO-ANCA Associated Lung Injury.

References for Phospho-AKT1-S473 Rabbit pAb (AP0140)

Product:

Phospho-AKT1-S473 Rabbit pAb

Journal:

Molecules

Application:

IF:

4.411

Species:

Dendrobium officinale Kimura et Migo

PMID:

30609689

Title:

Structure Identification of ViceninII Extracted from Dendrobium officinale and the Reversal of TGF-β1-Induced Epithelial?Mesenchymal Transition in Lung Adenocarcinoma Cells through TGF-β/Smad and PI3K/Akt/mTOR Signaling Pathways.

References for Phospho-AKT1-S473 Rabbit pAb (AP0140)

Product:

Phospho-AKT1-S473 Rabbit pAb

Journal:

Toxins

Application:

IF:

4.546

Species:

Homo sapiens

PMID:

30875960

Title:

Regulation of Microcystin-LR-Induced DNA Damage by miR-451a in HL7702 Cells.

References for Phospho-AKT1-S473 Rabbit pAb (AP0140)

Product:

Phospho-AKT1-S473 Rabbit pAb

Journal:

Frontiers in Physiology

Application:

IF:

4.566

Species:

Bovine

PMID:

30890956

Title:

Ganoderma triterpenes Protect Against Hyperhomocysteinemia Induced Endothelial-Mesenchymal Transition via TGF-β Signaling Inhibition.

References for Phospho-AKT1-S473 Rabbit pAb (AP0140)

Product:

Phospho-AKT1-S473 Rabbit pAb

Journal:

Anti-cancer Drugs

Application:

IF:

2.248

Species:

Homo sapiens

PMID:

31789625

Title:

Metformin mediated microRNA-7 upregulation inhibits growth, migration, and invasion of non-small cell lung cancer A549 cells

References for Phospho-AKT1-S473 Rabbit pAb (AP0140)

Product:

Phospho-AKT1-S473 Rabbit pAb

Journal:

Aging

Application:

IF:

5.682

Species:

Homo sapiens

PMID:

32454461

Title:

ZNF139/circZNF139 promotes cell proliferation, migration and invasion via activation of PI3K/AKT pathway in bladder cancer

References for Phospho-AKT1-S473 Rabbit pAb (AP0140)

Product:

Phospho-AKT1-S473 Rabbit pAb

Journal:

Onco Targets Ther

Application:

IF:

4.147

Species:

Homo sapiens

PMID:

32801743

Title:

Long Noncoding RNA ADAMTS9-AS2 Inhibits the Proliferation, Migration, and Invasion in Bladder Tumor Cells

References for Phospho-AKT1-S473 Rabbit pAb (AP0140)

Product:

Phospho-AKT1-S473 Rabbit pAb

Journal:

Anim Biotechnol

Application:

IF:

2.282

Species:

Capra hircus

PMID:

32730101

Title:

Pou2F3 silencing enhanced the proliferation of mammary epithelial cells in dairy goat via PI3K/AKT/mTOR signaling pathway

References for Phospho-AKT1-S473 Rabbit pAb (AP0140)

Product:

Phospho-AKT1-S473 Rabbit pAb

Journal:

Oncol Lett

Application:

IF:

2.967

Species:

Homo sapiens

PMID:

32934714

Title:

DEPDC1B promotes migration and invasion in pancreatic ductal adenocarcinoma by activating the Akt/GSK3尾/Snail pathway

References for Phospho-AKT1-S473 Rabbit pAb (AP0140)

Product:

Phospho-AKT1-S473 Rabbit pAb

Journal:

Food Chem Toxicol

Application:

IF:

6.023

Species:

Homo sapiens

PMID:

32619556

Title:

Glycolysis inhibition and apoptosis induction in human prostate cancer cells by FV-429-mediated regulation of AR-AKT-HK2 signaling network

References for Phospho-AKT1-S473 Rabbit pAb (AP0140)

Product:

Phospho-AKT1-S473 Rabbit pAb

Journal:

Am J Transl Res

Application:

IF:

4.06

Species:

Homo sapiens

PMID:

33042449

Title:

Long non-coding RNA ADAMTS9-AS1 exacerbates cell proliferation, migration, and invasion via triggering of the PI3K/AKT/mTOR pathway in hepatocellular …

References for Phospho-AKT1-S473 Rabbit pAb (AP0140)

Product:

Phospho-AKT1-S473 Rabbit pAb

Journal:

J Anim Sci Biotechnol

Application:

IF:

5.032

Species:

Capra hircus

PMID:

33072314

Title:

Effects of miR-101-3p on goat granulosa cells in vitro and ovarian development in vivo via STC1

References for Phospho-AKT1-S473 Rabbit pAb (AP0140)

Product:

Phospho-AKT1-S473 Rabbit pAb

Journal:

Biomed Mater

Application:

IF:

3.715

Species:

Homo sapiens

PMID:

32442992

Title:

A comparative study unraveling the effects of TNF-α stimulation on endothelial cells between 2D and 3D culture

References for Phospho-AKT1-S473 Rabbit pAb (AP0140)

Product:

Phospho-AKT1-S473 Rabbit pAb

Journal:

Drug Des Devel Ther

Application:

IF:

4.162

Species:

Homo sapiens

PMID:

33603340

Title:

Loganin Attenuates Septic Acute Renal Injury with the Participation of AKT and Nrf2/HO-1 Signaling Pathways

References for Phospho-AKT1-S473 Rabbit pAb (AP0140)

Product:

Phospho-AKT1-S473 Rabbit pAb

Journal:

Cancer Cell Int

Application:

IF:

5.722

Species:

Homo sapiens

PMID:

33588847

Title:

Loss of PR55α promotes proliferation and metastasis by activating MAPK/AKT signaling in hepatocellular carcinoma

References for Phospho-AKT1-S473 Rabbit pAb (AP0140)

Product:

Phospho-AKT1-S473 Rabbit pAb

Journal:

Life Sci

Application:

IF:

5.03

Species:

Homo sapiens

PMID:

33737087

Title:

Gigantol inhibits proliferation and enhances DDP-induced apoptosis in breast-cancer cells by downregulating the PI3K/Akt/mTOR signaling pathway

References for Phospho-AKT1-S473 Rabbit pAb (AP0140)

Product:

Phospho-AKT1-S473 Rabbit pAb

Journal:

Exp Ther Med

Application:

IF:

2.44

Species:

Homo sapiens

PMID:

33850531

Title:

Long non-coding RNA ADAMTS9-AS2 inhibits liver cancer cell proliferation, migration and invasion

References for Phospho-AKT1-S473 Rabbit pAb (AP0140)

Product:

Phospho-AKT1-S473 Rabbit pAb

Journal:

Carbohydr Polym .

Application:

IF:

9.381

Species:

Mus musculus

PMID:

33838836

Title:

Value added immunoregulatory polysaccharides of Hericium erinaceus and their effect on the gut microbiota

References for Phospho-AKT1-S473 Rabbit pAb (AP0140)

Product:

Phospho-AKT1-S473 Rabbit pAb

Journal:

Cell Cycle

Application:

WB, IF, IHC

IF:

4.53

Species:

Rattus norvegicus

PMID:

33685347

Title:

Exosomes derived from autologous dermal fibroblasts promote diabetic cutaneous wound healing through the Akt/β-catenin pathway

References for Phospho-AKT1-S473 Rabbit pAb (AP0140)

Product:

Phospho-AKT1-S473 Rabbit pAb

Journal:

Int Immunopharmacol

Application:

WB, IHC

IF:

4.93

Species:

Mus musculus

PMID:

33773208

Title:

Impaired airway epithelial barrier integrity was mediated by PI3Kδ in a mouse model of lipopolysaccharide-induced acute lung injury

References for Phospho-AKT1-S473 Rabbit pAb (AP0140)

Product:

Phospho-AKT1-S473 Rabbit pAb

Journal:

Acta Pharmacol Sin

Application:

IF:

6.15

Species:

Rattus norvegicus

PMID:

33976388

Title:

Brexpiprazole caused glycolipid metabolic disorder by inhibiting GLP1/GLP1R signaling in rats

References for Phospho-AKT1-S473 Rabbit pAb (AP0140)

Product:

Phospho-AKT1-S473 Rabbit pAb

Journal:

Food Chem Toxicol

Application:

IF:

6.02

Species:

Mus musculus

PMID:

34600025

Title:

Prenatal EGCG exposure-induced heart mass reduction in adult male mice and underlying mechanisms

References for Phospho-AKT1-S473 Rabbit pAb (AP0140)

Product:

Phospho-AKT1-S473 Rabbit pAb

Journal:

Respir Res

Application:

IF:

5.631

Species:

Mus musculus

PMID:

34098934

Title:

Ameliorative effects of eosinophil deficiency on immune response, endoplasmic reticulum stress, apoptosis, and autophagy in fungus-induced allergic lung inflammation

References for Phospho-AKT1-S473 Rabbit pAb (AP0140)

Product:

Phospho-AKT1-S473 Rabbit pAb

Journal:

Oncol Rep

Application:

IF:

3.906

Species:

Homo sapiens

PMID:

34643248

Title:

Berberine exerts its antineoplastic effects by reversing the Warburg effect via downregulation of the Akt/mTOR/GLUT1 signaling pathway

References for Phospho-AKT1-S473 Rabbit pAb (AP0140)

Product:

Phospho-AKT1-S473 Rabbit pAb

Journal:

Eur J Pharmacol

Application:

IF:

4.432

Species:

Mus musculus

PMID:

34481876

Title:

Loureirin B attenuates insulin resistance in HepG2 cells by regulating gluconeogenesis signaling pathway

References for Phospho-AKT1-S473 Rabbit pAb (AP0140)

Product:

Phospho-AKT1-S473 Rabbit pAb

Journal:

Oxid Med Cell Longev

Application:

IF:

6.543

Species:

Rattus norvegicus

PMID:

34707783

Title:

Increased Expression of Integrin Alpha 6 in Nucleus Pulposus Cells in Response to High Oxygen Tension Protects against Intervertebral Disc Degeneration

References for Phospho-AKT1-S473 Rabbit pAb (AP0140)

Product:

Phospho-AKT1-S473 Rabbit pAb

Journal:

J Trace Elem Med Biol

Application:

IF:

3.849

Species:

Homo sapiens

PMID:

34751137

Title:

Combination of zinc and selenium alleviates ochratoxin A-induced fibrosis via blocking ROS-dependent autophagy in HK-2 cells

References for Phospho-AKT1-S473 Rabbit pAb (AP0140)

Product:

Phospho-AKT1-S473 Rabbit pAb

Journal:

Phytomedicine

Application:

IF:

5.34

Species:

Apocynum venetum leaf

PMID:

34781232

Title:

Apocynum venetum leaf extract alleviated doxorubicin-induced cardiotoxicity through the AKT/Bcl-2 signaling pathway

References for Phospho-AKT1-S473 Rabbit pAb (AP0140)

Product:

Phospho-AKT1-S473 Rabbit pAb

Journal:

Food Funct

Application:

IF:

5.396

Species:

Mus musculus

PMID:

34821902

Title:

Ganoderic acid improves 5-fluorouracil-induced cognitive dysfunction in mice

References for Phospho-AKT1-S473 Rabbit pAb (AP0140)

Product:

Phospho-AKT1-S473 Rabbit pAb

Journal:

J Agric Food Chem

Application:

IF:

5.279

Species:

Mannan Oligosaccharide

PMID:

34542274

Title:

Mannan Oligosaccharide Could Attenuate Ochratoxin A-Induced Immunosuppression with Long-Time Exposure Instead of Immunostimulation with Short-Time …

References for Phospho-AKT1-S473 Rabbit pAb (AP0140)

Product:

Phospho-AKT1-S473 Rabbit pAb

Journal:

Front Pharmacol

Application:

IF:

5.81

Species:

Rattus norvegicus

PMID:

34646130

Title:

WTD Attenuating Rheumatoid Arthritis via Suppressing Angiogenesis and Modulating the PI3K/AKT/mTOR/HIF-1α Pathway

References for Phospho-AKT1-S473 Rabbit pAb (AP0140)

Product:

Phospho-AKT1-S473 Rabbit pAb

Journal:

International Journal of Molecular Sciences

Application:

IF:

5.923

Species:

Homo sapiens

PMID:

29882900

Title:

Isoviolanthin Extracted from Dendrobium officinale Reverses TGF-β1-Mediated Epithelial⁻Mesenchymal Transition in Hepatocellular Carcinoma Cells via Deactivating the TGF-β/Smad and PI3K/Akt/mTOR Signaling Pathways.

References for Phospho-AKT1-S473 Rabbit pAb (AP0140)

Product:

Phospho-AKT1-S473 Rabbit pAb

Journal:

Cancer biology & medicine

Application:

IF:

4.24

Species:

Homo sapiens

PMID:

33710804

Title:

SNORA23 inhibits HCC tumorigenesis by impairing the 2′-O-ribose methylation level of 28S rRNA

References for Phospho-AKT1-S473 Rabbit pAb (AP0140)

Product:

Phospho-AKT1-S473 Rabbit pAb

Journal:

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology

Application:

IF:

Species:

Mus musculus

PMID:

29495021

Title:

Dapagliflozin aggravates renal injury via promoting gluconeogenesis in db/db mice

References for Phospho-AKT1-S473 Rabbit pAb (AP0140)

Product:

Phospho-AKT1-S473 Rabbit pAb

Journal:

Science advances

Application:

IF:

14.14

Species:

Mus musculus

PMID:

35507647

Title:

α-Ketoglutaric acid ameliorates hyperglycemia in diabetes by inhibiting hepatic gluconeogenesis via serpina1e signaling

References for Phospho-AKT1-S473 Rabbit pAb (AP0140)

Product:

Phospho-AKT1-S473 Rabbit pAb

Journal:

Investigative ophthalmology & visual science

Application:

IF:

4.79

Species:

Mus musculus

PMID:

31415077

Title:

Corneal denervation causes epithelial apoptosis through inhibiting NAD+ biosynthesis

References for Phospho-AKT1-S473 Rabbit pAb (AP0140)

Product:

Phospho-AKT1-S473 Rabbit pAb

Journal:

Cancers

Application:

IF:

6.63

Species:

Homo sapiens

PMID:

35565203

Title:

Overexpression of GATA5 Inhibits Prostate Cancer Progression by Regulating PLAGL2 via the FAK/PI3K/AKT Pathway

References for Phospho-AKT1-S473 Rabbit pAb (AP0140)

Product:

Phospho-AKT1-S473 Rabbit pAb

Journal:

Journal of cellular physiology

Application:

IF:

6.38

Species:

Homo sapiens

PMID:

32020591

Title:

Long noncoding RNA TCL6 binds to miR‐106a‐5p to regulate hepatocellular carcinoma cells through PI3K/AKT signaling pathway

References for Phospho-AKT1-S473 Rabbit pAb (AP0140)

Product:

Phospho-AKT1-S473 Rabbit pAb

Journal:

Frontiers in cell and developmental biology

Application:

IF:

6.68

Species:

Mus musculus

PMID:

35445030

Title:

SHIP1 Activator AQX-1125 Regulates Osteogenesis and Osteoclastogenesis Through PI3K/Akt and NF-κb Signaling

References for Phospho-AKT1-S473 Rabbit pAb (AP0140)

Product:

Phospho-AKT1-S473 Rabbit pAb

Journal:

Bioengineered

Application:

IF:

3.26

Species:

Rattus norvegicus

PMID:

35420511

Title:

Research and experimental verification of the molecular mechanism of berberine in improving premature ovarian failure based on network pharmacology

References for Phospho-AKT1-S473 Rabbit pAb (AP0140)

Product:

Phospho-AKT1-S473 Rabbit pAb

Journal:

Journal of cellular and molecular medicine

Application:

IF:

5.31

Species:

Rattus norvegicus

PMID:

34953035

Title:

Glycyrrhizin regulates rat TMJOA progression by inhibiting the HMGB1‐RAGE/TLR4‐NF‐κB/AKT pathway

References for Phospho-AKT1-S473 Rabbit pAb (AP0140)

Product:

Phospho-AKT1-S473 Rabbit pAb

Journal:

Disease markers

Application:

IF:

3.464

Species:

Mus musculus

PMID:

35140821

Title:

Qing Zao Fang (QZF) Alleviates the Inflammatory Microenvironment of the Submandibular Gland in Sjögren's Syndrome Based on the PI3K/Akt/HIF-1 α /VEGF Signaling Pathway

References for Phospho-AKT1-S473 Rabbit pAb (AP0140)

Product:

Phospho-AKT1-S473 Rabbit pAb

Journal:

Molecular oncology

Application:

IF:

7.44

Species:

Mus musculus

PMID:

34758182

Title:

A small molecule targeting CHI3L1 inhibits lung metastasis by blocking IL‐13Rα2‐mediated JNK‐AP‐1 signals

References for Phospho-AKT1-S473 Rabbit pAb (AP0140)

Product:

Phospho-AKT1-S473 Rabbit pAb

Journal:

Molecular therapy : the journal of the American Society of Gene Therapy

Application:

IF:

12.91

Species:

Homo sapiens

PMID:

33068778

Title:

lncRNA SNHG11 promotes gastric cancer progression by activating the Wnt/β-catenin pathway and oncogenic autophagy

References for Phospho-AKT1-S473 Rabbit pAb (AP0140)

Product:

Phospho-AKT1-S473 Rabbit pAb

Journal:

Journal of pharmacological sciences

Application:

IF:

3.57

Species:

Mus musculus

PMID:

31400930

Title:

Schisandra chinensis acidic polysaccharide partialy reverses acetaminophen-induced liver injury in mice

References for Phospho-AKT1-S473 Rabbit pAb (AP0140)

Product:

Phospho-AKT1-S473 Rabbit pAb

Journal:

Frontiers in oncology

Application:

IHC

IF:

5.738

Species:

Homo sapiens,Mus musculus

PMID:

35111682

Title:

Agrin Promotes Non-Small Cell Lung Cancer Progression and Stimulates Regulatory T Cells via Increasing IL-6 Secretion Through PI3K/AKT Pathway

References for Phospho-AKT1-S473 Rabbit pAb (AP0140)

Product:

Phospho-AKT1-S473 Rabbit pAb

Journal:

Nutrients

Application:

IF:

6.7

Species:

Mus musculus

PMID:

35267996

Title:

Effects and Mechanisms of Rhus chinensis Mill. Fruits on Suppressing RANKL-Induced Osteoclastogenesis by Network Pharmacology and Validation in RAW264.7 Cells

References for Phospho-AKT1-S473 Rabbit pAb (AP0140)

Product:

Phospho-AKT1-S473 Rabbit pAb

Journal:

Nan fang yi ke da xue xue bao = Journal of Southern Medical University

Application:

IF:

Species:

Homo sapiens

PMID:

31340906

Title:

Matrine inhibits proliferation and promotes autophagy and apoptosis in non-small cell lung cancer cells by deactivating PI3K/AKT/mTOR pathway

References for Phospho-AKT1-S473 Rabbit pAb (AP0140)

Product:

Phospho-AKT1-S473 Rabbit pAb

Journal:

Current cancer drug targets

Application:

IF:

2.9

Species:

Homo sapiens

PMID:

30605061

Title:

Gefitinib represses JAK-STAT signaling activated by CRTC1-MAML2 fusion in mucoepidermoid carcinoma cells

References for Phospho-AKT1-S473 Rabbit pAb (AP0140)

Product:

Phospho-AKT1-S473 Rabbit pAb

Journal:

Oncology reports

Application:

IF:

4.13

Species:

Homo sapiens,Mus musculus

PMID:

35866591

Title:

Overexpressed lncRNA FTX promotes the cell viability, proliferation, migration and invasion of renal cell carcinoma via FTX/miR-4429/UBE2C axis - PMC

References for Phospho-AKT1-S473 Rabbit pAb (AP0140)

Product:

Phospho-AKT1-S473 Rabbit pAb

Journal:

Oxidative medicine and cellular longevity

Application:

IF:

7.31

Species:

Mus musculus

PMID:

35770048

Title:

DJ-1/FGFR-1 Signaling Pathway Contributes to Sorafenib Resistance in Hepatocellular Carcinoma - PMC

References for Phospho-AKT1-S473 Rabbit pAb (AP0140)

Product:

Phospho-AKT1-S473 Rabbit pAb

Journal:

Journal of controlled release : official journal of the Controlled Release Society

Application:

IF:

11.46

Species:

Rattus norvegicus

PMID:

36493946

Title:

Modified CFBP-bFGF targeting to ischemic brain promoted the functional recovery of cerebral ischemia

References for Phospho-AKT1-S473 Rabbit pAb (AP0140)

Product:

Phospho-AKT1-S473 Rabbit pAb

Journal:

Frontiers in pharmacology

Application:

WB, IF/ICC

IF:

5.98

Species:

Homo sapiens,Mus musculus

PMID:

36582530

Title:

Hydroxy-α-sanshool isolated from Zanthoxylum bungeanum Maxim. has antidiabetic effects on high-fat-fed and streptozotocin-treated mice via increasing glycogen synthesis by regulation of PI3K/Akt/GSK-3β/GS signaling - PMC

References for Phospho-AKT1-S473 Rabbit pAb (AP0140)

Product:

Phospho-AKT1-S473 Rabbit pAb

Journal:

International immunopharmacology

Application:

IF:

5.71

Species:

Mus musculus

PMID:

36689848

Title:

pNaktide mitigates inflammation-induced neuronal damage and behavioral deficits through the oxidative stress pathway

References for Phospho-AKT1-S473 Rabbit pAb (AP0140)

Product:

Phospho-AKT1-S473 Rabbit pAb

Journal:

BMC pulmonary medicine

Application:

IF:

3.32

Species:

Homo sapiens

PMID:

35842617

Title:

LncRNA LINC00511 promotes COL1A1-mediated proliferation and metastasis by sponging miR-126-5p/miR-218-5p in lung adenocarcinoma - PMC

References for Phospho-AKT1-S473 Rabbit pAb (AP0140)

Product:

Phospho-AKT1-S473 Rabbit pAb

Journal:

International journal of molecular sciences

Application:

IF:

6.2

Species:

Homo sapiens

PMID:

36292923

Title:

Diclofenac Sensitizes Signet Ring Cell Gastric Carcinoma Cells to Cisplatin by Activating Autophagy and Inhibition of Survival Signal Pathways - PMC

References for Phospho-AKT1-S473 Rabbit pAb (AP0140)

Product:

Phospho-AKT1-S473 Rabbit pAb

Journal:

Frontiers in pharmacology

Application:

WB, IF

IF:

5.98

Species:

Rattus norvegicus

PMID:

36313310

Title:

Monomethyl lithospermate alleviates ischemic stroke injury in middle cerebral artery occlusion mice in vivo and protects oxygen glucose deprivation/reoxygenation induced SHSY-5Y cells in vitro via activation of PI3K/Akt signaling - PMC

References for Phospho-AKT1-S473 Rabbit pAb (AP0140)

Product:

Phospho-AKT1-S473 Rabbit pAb

Journal:

Tissue engineering. Part A

Application:

IF:

4.08

Species:

Homo sapiens

PMID:

36305369

Title:

The UC-MSCbFGF/scaffold system accelerates the healing of the uterine full-thickness injury

References for Phospho-AKT1-S473 Rabbit pAb (AP0140)

Product:

Phospho-AKT1-S473 Rabbit pAb

Journal:

Bone

Application:

IF:

4.62

Species:

Mus musculus,Homo sapiens

PMID:

36702335

Title:

Legumain Inhibitor Prevents Breast Cancer Bone Metastasis by Attenuating Osteoclast Differentiation and Function

References for Phospho-AKT1-S473 Rabbit pAb (AP0140)

Product:

Phospho-AKT1-S473 Rabbit pAb

Journal:

Frontiers in pharmacology

Application:

IF, WB

IF:

5.98

Species:

Rattus norvegicus

PMID:

36091821

Title:

Alpiniae oxyphyllae fructus possesses neuroprotective effects on H2O2 stimulated PC12 cells via regulation of the PI3K/Akt signaling Pathway - PMC

References for Phospho-AKT1-S473 Rabbit pAb (AP0140)

Product:

Phospho-AKT1-S473 Rabbit pAb

Journal:

Biochimica et biophysica acta. Molecular cell research

Application:

IF:

5.01

Species:

Homo sapiens

PMID:

35649481

Title:

When "No-Smoking" is not enough: Hypoxia and nicotine acetylcholine receptor signaling may drive lung adenocarcinoma progression in never-smokers

References for Phospho-AKT1-S473 Rabbit pAb (AP0140)

Product:

Phospho-AKT1-S473 Rabbit pAb

Journal:

Poultry science

Application:

IF:

4.01

Species:

Gallus gallus

PMID:

36621100

Title:

Ligusticum chuanxiong promotes the angiogenesis of preovulatory follicles (F1-F3) in late-phase laying hens

References for Phospho-AKT1-S473 Rabbit pAb (AP0140)

Product:

Phospho-AKT1-S473 Rabbit pAb

Journal:

Infection and immunity

Application:

IF:

3.6

Species:

Homo sapiens

PMID:

35130451

Title:

The Anti-Apoptotic Role of COX-2 during In Vitro Infection of Human Intestinal Cell Line by Giardia duodenalis and The Potential Regulators

References for Phospho-AKT1-S473 Rabbit pAb (AP0140)

Product:

Phospho-AKT1-S473 Rabbit pAb

Journal:

Archives of medical research

Application:

IF:

8.32

Species:

Homo sapiens

PMID:

35164979

Title:

LncRNA NORAD Mediates the Proliferation and Apoptosis of Diffuse Large-B-Cell Lymphoma via Regulation of miR-345-3p/TRAF6 Axis

References for Phospho-AKT1-S473 Rabbit pAb (AP0140)

Product:

Phospho-AKT1-S473 Rabbit pAb

Journal:

Frontiers in pharmacology

Application:

IF:

5.98

Species:

Mus musculus

PMID:

36147330

Title:

EGCG protects the mouse brain against cerebral ischemia/reperfusion injury by suppressing autophagy via the AKT/AMPK/mTOR phosphorylation pathway - PMC

References for Phospho-AKT1-S473 Rabbit pAb (AP0140)

Product:

Phospho-AKT1-S473 Rabbit pAb

Journal:

European review for medical and pharmacological sciences

Application:

IF:

3.78

Species:

Homo sapiens

PMID:

36876711

Title:

An investigation into the mechanism of nobiletin's inhibition of papillary thyroid cancer using network pharmacology analysis and experimental pharmacology

References for Phospho-AKT1-S473 Rabbit pAb (AP0140)

Product:

Phospho-AKT1-S473 Rabbit pAb

Journal:

Journal of endocrinological investigation

Application:

IF:

5.46

Species:

Mus musculus

PMID:

36692817

Title:

A novel combination of sitagliptin and melatonin ameliorates T2D manifestations: studies on experimental diabetic models

References for Phospho-AKT1-S473 Rabbit pAb (AP0140)

Product:

Phospho-AKT1-S473 Rabbit pAb

Journal:

Cytokine

Application:

IF:

3.92

Species:

Rattus norvegicus

PMID:

36716676

Title:

Majoon chobchini reinstates PDL-1 expression and blocks dendritic cell-T helper 17 pathogenic axis in rheumatoid arthritis animal model

References for Phospho-AKT1-S473 Rabbit pAb (AP0140)

Product:

Phospho-AKT1-S473 Rabbit pAb

Journal:

PLoS pathogens

Application:

IF:

7.46

Species:

Sus scrofa

PMID:

36735752

Title:

Picornavirus infection enhances aspartate by the SLC38A8 transporter to promote viral replication - PMC

References for Phospho-AKT1-S473 Rabbit pAb (AP0140)

Product:

Phospho-AKT1-S473 Rabbit pAb

Journal:

International journal of molecular sciences

Application:

WB，IHC，IF

IF:

6.2

Species:

Homo sapiens

PMID:

36982218

Title:

HSPA5 Promotes the Proliferation, Metastasis and Regulates Ferroptosis of Bladder Cancer - PMC

References for Phospho-AKT1-S473 Rabbit pAb (AP0140)

Product:

Phospho-AKT1-S473 Rabbit pAb

Journal:

J Ethnopharmacol

Application:

IF:

5.195

Species:

Rattus norvegicus

PMID:

33839199

Title:

Aloe vera mitigates dextran sulfate sodium-induced rat ulcerative colitis by potentiating colon mucus barrier

References for Phospho-AKT1-S473 Rabbit pAb (AP0140)

Product:

Phospho-AKT1-S473 Rabbit pAb

Journal:

Molecules (Basel, Switzerland)

Application:

IF:

4.92

Species:

Homo sapiens

PMID:

36838918

Title:

Confusoside from Anneslea fragrans Alleviates Acetaminophen-Induced Liver Injury in HepG2 via PI3K-CASP3 Signaling Pathway - PMC

References for Phospho-AKT1-S473 Rabbit pAb (AP0140)

Product:

Phospho-AKT1-S473 Rabbit pAb

Journal:

Cancer gene therapy

Application:

IF:

5.85

Species:

Homo sapiens

PMID:

36241701

Title:

VEZF1, destabilized by STUB1, affects cellular growth and metastasis of hepatocellular carcinoma by transcriptionally regulating PAQR4

References for Phospho-AKT1-S473 Rabbit pAb (AP0140)

Product:

Phospho-AKT1-S473 Rabbit pAb

Journal:

The Journal of nutritional biochemistry

Application:

IF:

6.11

Species:

Mus musculus

PMID:

37023933

Title:

Ketogenic Diet Alleviates Renal Interstitial Fibrosis in UUO Mice by Regulating Macrophage Proliferation

References for Phospho-AKT1-S473 Rabbit pAb (AP0140)

Product:

Phospho-AKT1-S473 Rabbit pAb

Journal:

International journal of oral science

Application:

IF:

24.89

Species:

Mus musculus

PMID:

37198150

Title:

CD301b+ macrophage: the new booster for activating bone regeneration in periodontitis treatment - PMC

References for Phospho-AKT1-S473 Rabbit pAb (AP0140)

Product:

Phospho-AKT1-S473 Rabbit pAb

Journal:

Foods (Basel, Switzerland)

Application:

IF:

5.56

Species:

Mus musculus

PMID:

37048289

Title:

Theabrownin Isolated from Pu-Erh Tea Enhances the Innate Immune and Anti-Inflammatory Effects of RAW264.7 Macrophages via the TLR2/4-Mediated Signaling Pathway - PMC

References for Phospho-AKT1-S473 Rabbit pAb (AP0140)

Product:

Phospho-AKT1-S473 Rabbit pAb

Journal:

Journal of ethnopharmacology

Application:

IF:

5.19

Species:

Rattus norvegicus

PMID:

37201664

Title:

The mechanism of action of safflower total flavonoids in the treatment of endometritis caused by incomplete abortion based on network pharmacology and 16S rDNA …

References for Phospho-AKT1-S473 Rabbit pAb (AP0140)

Product:

Phospho-AKT1-S473 Rabbit pAb

Journal:

Life (Basel, Switzerland)

Application:

IF:

3.25

Species:

Mus musculus

PMID:

37109458