Overview
Product name
Pan Acetyl-Lysine Rabbit pAb
Catalog No.
A2391
Host species
Rabbit
Purification method
Affinity purification
Isotype
IgG
Background
Acetylation of lysine, like phosphorylation of serine, threonine or tyrosine, is an important reversible modification controlling protein activity. The conserved amino-terminal domains of the four core histones (H2A, H2B, H3, and H4) contain lysines that are acetylated by histone acetyltransferases (HATs) and deacetylated by histone deacetylases (HDACs) . Signaling resulting in acetylation/deacetylation of histones, transcription factors, and other proteins affects a diverse array of cellular processes including chromatin structure and gene activity, cell growth, differentiation, and apoptosis . Recent proteomic surveys suggest that acetylation of lysine residues may be a widespread and important form of post-translational protein modification that affects thousands of proteins involved in control of cell cycle and metabolism, longevity, actin polymerization, and nuclear transport . The regulation of protein acetylation status is impaired in cancer and polyglutamine diseases, and HDACs have become promising targets for anti-cancer drugs currently in development .
Immunogen information
Immunogen
A synthetic peptide corresponding to a sequence containing acetylated K.
Sequence
Email for sequence
Gene ID
Swiss prot
Synonyms
Calculated MW
Observed MW
Refer to figures
Applications
Reactivity
Human, Mouse, Rat, Other (Wide Range)
Tested applications
WB IHC-P IF/ICC IP ChIP ChIP-seq RIP FC FC(Intra) ELISA MeDIP Nucleotide Array DB FACS CoIP FCM CUT&Tag meRIP Inhibition
Recommended dilution
WB 1:500 - 1:1000IF/ICC 1:50 - 1:200
Storage buffer
Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.01% thimerosal, 50% glycerol, pH7.3.
Application key
Western blotting Immunofluorescence
Positive samples
HeLa, NIH/3T3, C6
Cellular location
Customer validation
WB (Mus musculus, Homo sapiens)
Co-IP (Mus musculus, Homo sapiens)
IP (Danio rerio, Homo sapiens, Mus musculus)
Pan Acetyl-Lysine Rabbit pAb images
Immunofluorescence - Pan Acetyl-Lysine Rabbit pAb (A2391)
Immunofluorescence analysis of HeLa TSA and HeLa cells using Pan Acetyl-Lysine Rabbit pAb (A2391) at dilution of 1:50 (40x lens). Secondary antibody: Cy3 Goat Anti-Rabbit IgG (H+L) (AS007) at 1:500 dilution. Blue: DAPI for nuclear staining.
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Related Targets
Based on existing publications, the following genes are closely related to research on pan Acetyl-K . (Numbers indicate number of published articles where
both targets appear.)
Related Research Area
Based on existing publications, the following research topics are related to pan Acetyl-K . (Distance between topics and target gene
indicate popularity.) pan Acetyl-K
* Data provided by citexs.com ,
for reference only.
References for Pan Acetyl-Lysine Rabbit pAb (A2391)
Product:
Pan Acetyl-Lysine Rabbit pAb
Journal:
Vascular Pharmacology
Application:
WB
IF:
5.773
Species:
Mus musculus
PMID:
Title:
G004, a synthetic sulfonylurea compound, exerts anti-atherosclerosis effects by targeting SIRT1 in ApoE(-/-) mice
References for Pan Acetyl-Lysine Rabbit pAb (A2391)
Product:
Pan Acetyl-Lysine Rabbit pAb
Journal:
Oxidative Medicine and Cellular Longevity
Application:
WB
IF:
6.543
Species:
Homo sapiens
PMID:
Title:
Bovine Herpesvirus 1 Productive Infection Led to Inactivation of Nrf2 Signaling through Diverse Approaches
References for Pan Acetyl-Lysine Rabbit pAb (A2391)
Product:
Pan Acetyl-Lysine Rabbit pAb
Journal:
Laboratory Investigation; a Journal of Technical Methods and Pathology
Application:
Co-IP
IF:
5.662
Species:
Mus musculus
PMID:
Title:
Polydatin protects against lipopolysaccharide-induced endothelial barrier disruption via SIRT3 activation
References for Pan Acetyl-Lysine Rabbit pAb (A2391)
Product:
Pan Acetyl-Lysine Rabbit pAb
Journal:
Autophagy
Application:
IP
IF:
16.016
Species:
Danio rerio
PMID:
Title:
CERKL regulates autophagy via the NAD-dependent deacetylase SIRT1
References for Pan Acetyl-Lysine Rabbit pAb (A2391)
Product:
Pan Acetyl-Lysine Rabbit pAb
Journal:
International Journal of Molecular Medicine
Application:
WB
IF:
4.101
Species:
Homo sapiens
PMID:
Title:
SIRT1 activation alleviates brain microvascular endothelial dysfunction in peroxisomal disorders.
References for Pan Acetyl-Lysine Rabbit pAb (A2391)
Product:
Pan Acetyl-Lysine Rabbit pAb
Journal:
Front Pharmacol
Application:
WB
IF:
5.81
Species:
Mus musculus
PMID:
Title:
Trimetazidine Inhibits Renal Tubular Epithelial Cells to Mesenchymal Transition in Diabetic Rats via Upregulation of Sirt1
References for Pan Acetyl-Lysine Rabbit pAb (A2391)
Product:
Pan Acetyl-Lysine Rabbit pAb
Journal:
Cell Death Dis
Application:
IP
IF:
8.469
Species:
Homo sapiens
PMID:
Title:
SIRT1 attenuates sepsis-induced acute kidney injury via Beclin1 deacetylation-mediated autophagy activation.
References for Pan Acetyl-Lysine Rabbit pAb (A2391)
Product:
Pan Acetyl-Lysine Rabbit pAb
Journal:
Clin Transl Med
Application:
WB
IF:
11.49
Species:
Homo sapiens
PMID:
Title:
Natural HDAC-1/8 inhibitor baicalein exerts therapeutic effect in CBF-AML
References for Pan Acetyl-Lysine Rabbit pAb (A2391)
Product:
Pan Acetyl-Lysine Rabbit pAb
Journal:
Front Pharmacol
Application:
WB
IF:
5.81
Species:
Mus musculus
PMID:
Title:
N-Acetyl Cysteine Ameliorates High-Fat Diet-Induced Nonalcoholic Fatty Liver Disease and Intracellular Triglyceride Accumulation by Preserving Mitochondrial Function
References for Pan Acetyl-Lysine Rabbit pAb (A2391)
Product:
Pan Acetyl-Lysine Rabbit pAb
Journal:
Pharmacol Res
Application:
WB
IF:
7.658
Species:
Mus musculus
PMID:
Title:
Liraglutide protects against lethal renal ischemia-reperfusion injury by inhibiting high-mobility group box 1 nuclear-cytoplasmic translocation and release
References for Pan Acetyl-Lysine Rabbit pAb (A2391)
Product:
Pan Acetyl-Lysine Rabbit pAb
Journal:
Autophagy
Application:
WB
IF:
16.016
Species:
Mus musculus
PMID:
Title:
CDK9 inhibition blocks the initiation of PINK1-PRKN-mediated mitophagy by regulating the SIRT1-FOXO3-BNIP3 axis and enhances the therapeutic effects involving mitochondrial dysfunction in hepatocellular carcinoma
References for Pan Acetyl-Lysine Rabbit pAb (A2391)
Product:
Pan Acetyl-Lysine Rabbit pAb
Journal:
Front Oncol
Application:
WB
IF:
6.244
Species:
Mus musculus
PMID:
Title:
Positive Reciprocal Feedback of lncRNA ZEB1-AS1 and HIF-1 α Contributes to Hypoxia-Promoted Tumorigenesis and Metastasis of Pancreatic Cancer
References for Pan Acetyl-Lysine Rabbit pAb (A2391)
Product:
Pan Acetyl-Lysine Rabbit pAb
Journal:
Front Endocrinol (Lausanne)
Application:
WB
IF:
5.555
Species:
Homo sapiens
PMID:
Title:
Quantitative Acetylomics Revealed Acetylation-Mediated Molecular Pathway Network Changes in Human Nonfunctional Pituitary Neuroendocrine Tumors
References for Pan Acetyl-Lysine Rabbit pAb (A2391)
Product:
Pan Acetyl-Lysine Rabbit pAb
Journal:
Oncotarget
Application:
WB
IF:
3.765
Species:
Mus musculus
PMID:
Title:
SIRT1 inhibition promotes atherosclerosis through impaired autophagy
References for Pan Acetyl-Lysine Rabbit pAb (A2391)
Product:
Pan Acetyl-Lysine Rabbit pAb
Journal:
Acta pharmaceutica Sinica. B
Application:
WB
IF:
11.41
Species:
Homo sapiens
PMID:
Title:
A novel SIRT6 activator ameliorates neuroinflammation and ischemic brain injury via EZH2/FOXC1 axis
References for Pan Acetyl-Lysine Rabbit pAb (A2391)
Product:
Pan Acetyl-Lysine Rabbit pAb
Journal:
Science advances
Application:
WB
IF:
14.14
Species:
Mus musculus
PMID:
Title:
Muscle mitochondrial remodeling by intermittent glucocorticoid drugs requires an intact circadian clock and muscle PGC1α
References for Pan Acetyl-Lysine Rabbit pAb (A2391)
Product:
Pan Acetyl-Lysine Rabbit pAb
Journal:
Cancer letters
Application:
WB
IF:
8.67
Species:
Homo sapiens
PMID:
Title:
NCAPD2 inhibits autophagy by regulating Ca2+/CAMKK2/AMPK/mTORC1 pathway and PARP-1/SIRT1 axis to promote colorectal cancer
References for Pan Acetyl-Lysine Rabbit pAb (A2391)
Product:
Pan Acetyl-Lysine Rabbit pAb
Journal:
Molecular metabolism
Application:
WB
IF:
8.56
Species:
Mus musculus
PMID:
Title:
Pgc-1α controls epidermal stem cell fate and skin repair by sustaining NAD+ homeostasis during aging
References for Pan Acetyl-Lysine Rabbit pAb (A2391)
Product:
Pan Acetyl-Lysine Rabbit pAb
Journal:
Folia histochemica et cytobiologica
Application:
IP
IF:
1.49
Species:
Mus musculus
PMID:
Title:
HDAC5 inhibits ovarian angiogenesis in dehydroepiandrosterone-induced mouse model of polycystic ovary syndrome
References for Pan Acetyl-Lysine Rabbit pAb (A2391)
Product:
Pan Acetyl-Lysine Rabbit pAb
Journal:
Clinical science (London, England : 1979)
Application:
WB
IF:
6.87
Species:
Mus musculus,Homo sapiens
PMID:
Title:
Metformin alleviates HFD-induced oxidative stress in hepatocyte via activating SIRT6/PGC-1α/ENDOG signaling
References for Pan Acetyl-Lysine Rabbit pAb (A2391)
Product:
Pan Acetyl-Lysine Rabbit pAb
Journal:
Science advances
Application:
IP
IF:
14.95
Species:
Homo sapiens
PMID:
Title:
Lactate promotes endothelial-to-mesenchymal transition via Snail1 lactylation after myocardial infarction - PMC
References for Pan Acetyl-Lysine Rabbit pAb (A2391)
Product:
Pan Acetyl-Lysine Rabbit pAb
Journal:
Journal of agricultural and food chemistry
Application:
WB
IF:
5.89
Species:
Mus musculus
PMID:
Title:
Ginsenoside Rc Modulates SIRT6-NRF2 Interaction to Alleviate Alcoholic Liver Disease
References for Pan Acetyl-Lysine Rabbit pAb (A2391)
Product:
Pan Acetyl-Lysine Rabbit pAb
Journal:
Journal of virology
Application:
WB
IF:
6.54
Species:
Homo sapiens
PMID:
Title:
SETD6 Regulates E2-Dependent Human Papillomavirus Transcription
References for Pan Acetyl-Lysine Rabbit pAb (A2391)
Product:
Pan Acetyl-Lysine Rabbit pAb
Journal:
Cellular and molecular life sciences : CMLS
Application:
WB
IF:
9.2
Species:
Mus musculus
PMID:
Title:
A novel mechanism for the protection against acute lung injury by melatonin: mitochondrial quality control of lung epithelial cells is preserved through SIRT3 …
References for Pan Acetyl-Lysine Rabbit pAb (A2391)
Product:
Pan Acetyl-Lysine Rabbit pAb
Journal:
The Journal of biological chemistry
Application:
Co-IP
IF:
0
Species:
Homo sapiens
PMID:
Title:
Acetylation stabilizes the signaling protein WISP2 by preventing its degradation to suppress the progression of acute myeloid leukemia
References for Pan Acetyl-Lysine Rabbit pAb (A2391)
Product:
Pan Acetyl-Lysine Rabbit pAb
Journal:
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Application:
WB
IF:
7.41
Species:
Homo sapiens
PMID:
Title:
p53 deacetylation alleviates calcium oxalate deposition-induced renal fibrosis by inhibiting ferroptosis
References for Pan Acetyl-Lysine Rabbit pAb (A2391)
Product:
Pan Acetyl-Lysine Rabbit pAb
Journal:
Experimental and therapeutic medicine
Application:
WB
IF:
2.75
Species:
Mus musculus
PMID:
Title:
Pachymic acid modulates sirtuin 6 activity to alleviate lipid metabolism disorders - PMC
References for Pan Acetyl-Lysine Rabbit pAb (A2391)
Product:
Pan Acetyl-Lysine Rabbit pAb
Journal:
Molecular medicine (Cambridge, Mass.)
Application:
Co-IP
IF:
6.37
Species:
Mus musculus
PMID:
Title:
Microglia Sirt6 modulates the transcriptional activity of NRF2 to ameliorate high-fat diet-induced obesity - PMC
Publishing research using A2391? Please let
us know so that we can cite the reference in this datasheet.
* For research use only. Not for therapeutic or diagnostic
purposes.