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MLKL Rabbit mAb (A17207)

Datasheet

Overview

Product nameMLKL Rabbit mAb
Catalog No.A17207
Host speciesRabbit
Purification methodAffinity purification
IsotypeIgG
This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene.
ImmunogenRecombinant protein of human MLKL.
SequenceEmail for sequence
Gene ID197259
Swiss protQ8NB16
SynonymshMLKL; MLKL
Calculated MW30kDa/54kDa
Observed MWRefer to figures
Reactivity
Tested applicationsWBIHCICCIFIPChIPChIPseqRIPFCELISAMeDIPNucleotide Array
Recommended dilutionWB 1:500 - 1:2000
IHC 1:50 - 1:200
Storage bufferStore at -20℃. Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Application keyWestern blotting    Immunohistochemistry    
Positive samples
Cellular location

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