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LRP1 Rabbit pAb (A1439)

Review (1)Publications (2) Datasheet

ABclonal:Western blot - LRP1 Rabbit pAb (A1439)
ABclonal:Immunohistochemistry - LRP1 Rabbit pAb (A1439)
ABclonal:Immunohistochemistry - LRP1 Rabbit pAb (A1439)
ABclonal:Immunohistochemistry - LRP1 Rabbit pAb (A1439)
Review
ABclonal: review for LRP1 Rabbit pAb(A1439)

Overview

Product nameLRP1 Rabbit pAb
Catalog No.A1439
Host speciesRabbit
Purification methodAffinity purification
IsotypeIgG
This gene encodes a member of the low-density lipoprotein receptor family of proteins. The encoded preproprotein is proteolytically processed by furin to generate 515 kDa and 85 kDa subunits that form the mature receptor (PMID: 8546712). This receptor is involved in several cellular processes, including intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. In addition, the encoded protein is necessary for the alpha 2-macroglobulin-mediated clearance of secreted amyloid precursor protein and beta-amyloid, the main component of amyloid plaques found in Alzheimer patients. Expression of this gene decreases with age and has been found to be lower than controls in brain tissue from Alzheimer's disease patients.
ImmunogenRecombinant fusion protein containing a sequence corresponding to amino acids 20-270 of human LRP1 (NP_002323.2).
SequenceAIDAPKTCSPKQFACRDQITCISKGWRCDGERDCPDGSDEAPEICPQSKAQRCQPNEHNCLGTELCVPMSRLCNGVQDCMDGSDEGPHCRELQGNCSRLGCQHHCVPTLDGPTCYCNSSFQLQADGKTCKDFDECSVYGTCSQLCTNTDGSFICGCVEGYLLQPDNRSCKAKNEPVDRPPVLLIANSQNILATYLSGAQVSTITPTSTRQTTAMDFSYANETVCWVHVGDSAAQTQLKCARMPGLKGFVDE
Gene ID4035
Swiss protQ07954
SynonymsLRP1; A2MR; APOER; APR; CD91; IGFBP3R; KPA; LRP; LRP1A; TGFBR5
Calculated MW31kDa/504kDa
Observed MW505kDa
ReactivityHuman, Mouse, Rat
Tested applicationsWBIHCICCIFIPChIPChIPseqRIPFCELISAMeDIPNucleotide ArrayDB
Recommended dilutionWB 1:500 - 1:1000
IHC 1:50 - 1:100
Storage bufferStore at -20℃. Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Application keyWestern blotting    Immunohistochemistry    
Positive samplesMouse brain
Cellular locationCell membrane, Cytoplasm, Extracellular side, Membrane, Nucleus, Peripheral membrane protein, Single-pass type I membrane protein, coated pit
Customer validation

(Mouse embryonal fibroblast cell)

WB(, Mus musculus)

ABclonal:Western blot - LRP1 Rabbit pAb (A1439) }

Western blot - LRP1 Rabbit pAb (A1439)

Western blot analysis of extracts of Mouse brain, using LRP1 Rabbit pAb (A1439) at 1:1000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit (RM00020).
Exposure time: 180s.
ABclonal:Immunohistochemistry - LRP1 Rabbit pAb (A1439) }

Immunohistochemistry - LRP1 Rabbit pAb (A1439)

Immunohistochemistry of paraffin-embedded rat ovary using LRP1 antibody (A1439) at dilution of 1:100 (40x lens).
ABclonal:Immunohistochemistry - LRP1 Rabbit pAb (A1439) }

Immunohistochemistry - LRP1 Rabbit pAb (A1439)

Immunohistochemistry of paraffin-embedded human liver cancer using LRP1 antibody (A1439) at dilution of 1:100 (40x lens).
ABclonal:Immunohistochemistry - LRP1 Rabbit pAb (A1439) }

Immunohistochemistry - LRP1 Rabbit pAb (A1439)

Immunohistochemistry of paraffin-embedded human placenta using LRP1 antibody (A1439) at dilution of 1:100 (40x lens).

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