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[KO Validated] DPYSL2 Rabbit pAb (A14570)

Datasheet

ABclonal:Western blot - [KO Validated] DPYSL2 Rabbit pAb (A14570)
ABclonal:Western blot - [KO Validated] DPYSL2 Rabbit pAb (A14570)
ABclonal:Immunohistochemistry - [KO Validated] DPYSL2 Rabbit pAb (A14570)
ABclonal:Immunohistochemistry - [KO Validated] DPYSL2 Rabbit pAb (A14570)

Overview

Product name[KO Validated] DPYSL2 Rabbit pAb
Catalog No.A14570
Host speciesRabbit
Purification methodAffinity purification
IsotypeIgG
This gene encodes a member of the collapsin response mediator protein family. Collapsin response mediator proteins form homo- and hetero-tetramers and facilitate neuron guidance, growth and polarity. The encoded protein promotes microtubule assembly and is required for Sema3A-mediated growth cone collapse, and also plays a role in synaptic signaling through interactions with calcium channels. This gene has been implicated in multiple neurological disorders, and hyperphosphorylation of the encoded protein may play a key role in the development of Alzheimer's disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
ImmunogenA synthetic peptide corresponding to a sequence within amino acids 400-500 of human DPYSL2 (NP_001377.1).
SequenceRIAVGSDADLVIWDPDSVKTISAKTHNSSLEYNIFEGMECRGSPLVVISQGKIVLEDGTLHVTEGSGRYIPRKPFPDFVYKRIKARSRLAELRGVPRGLYD
Gene ID1808
Swiss protQ16555
SynonymsDPYSL2; CRMP-2; CRMP2; DHPRP2; DRP-2; DRP2; N2A3; ULIP-2; ULIP2
Calculated MW58kDa/62kDa
Observed MW62kDa
ReactivityHuman, Mouse, Rat
Tested applicationsWBIHCICCIFIPChIPChIPseqRIPFCELISAMeDIPNucleotide ArrayDB
Recommended dilutionWB 1:500 - 1:2000
IHC 1:50 - 1:200
Storage bufferStore at -20℃. Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Application keyWestern blotting    Immunohistochemistry    
Positive samplesHepG2, U-251MG, 293T
Cellular locationCytoplasm, Membrane, cytoskeleton, cytosol
ABclonal:Western blot - [KO Validated] DPYSL2 Rabbit pAb (A14570) }

Western blot - [KO Validated] DPYSL2 Rabbit pAb (A14570)

Western blot analysis of extracts of various cell lines, using DPYSL2 antibody (A14570) at 1:1000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit (RM00020).
Exposure time: 10s.
ABclonal:Western blot - [KO Validated] DPYSL2 Rabbit pAb (A14570) }

Western blot - [KO Validated] DPYSL2 Rabbit pAb (A14570)

Western blot analysis of extracts from normal (control) and DPYSL2 knockout (KO) HeLa cells, using DPYSL2 antibody (A14570) at 1:3000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit (RM00020).
Exposure time: 5s.
ABclonal:Immunohistochemistry - [KO Validated] DPYSL2 Rabbit pAb (A14570) }

Immunohistochemistry - [KO Validated] DPYSL2 Rabbit pAb (A14570)

Immunohistochemistry of paraffin-embedded rat brain using [KO Validated] DPYSL2 Rabbit pAb (A14570) at dilution of 1:400 (40x lens).
ABclonal:Immunohistochemistry - [KO Validated] DPYSL2 Rabbit pAb (A14570) }

Immunohistochemistry - [KO Validated] DPYSL2 Rabbit pAb (A14570)

Immunohistochemistry of paraffin-embedded mouse brain using [KO Validated] DPYSL2 Rabbit pAb (A14570) at dilution of 1:400 (40x lens).

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