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Rhesus TGF-beta 2 Gene ORF cDNA clone expression plasmid, C-GFPSpark tag

Catalog No:CG90036-ACG
NCBI RefSeq:1245 bp
Type:Expression-Ready ORF Clones
Gene ID:

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TGF beta 2 (Transforming growth factor beta 2), an extracellular glycosylated protein, which belongs to the TGF-beta family. TGF-beta regulates key mechanisms of tumor development, namely immunosuppression, metastasis, angiogenesis, and proliferation. TGF beta 2 suppression is a promising therapeutic approach for malignant tumor therapy. The signaling pathway of TGF beta 2/Smad plays an important role in the pathological process in posterior capsule opacification (PCO) after cataract surgery. Silencing Smad2 and Smad3 efficiently blocked the effect of TGF beta 2 on cell proliferation, migration, and extracellular matrix production. TGF beta 2 activation of MEKK3/ERK1/2/5 signaling modulates Has2 expression and hyaluronan (HA) production leading to the induction of epithelial to mesenchymal transformation (EMT) events. In addition, the upregulation of the TGF beta 2 level is a common pathological feature of Alzheimer's disease (AD) brains and sµggests that it may be closely linked to the development of neuronal death related to AD.

Rhesus TGF-beta 2 Gene ORF cDNA clone expression plasmid, C-GFPSpark tag Product information

Molecule NameTGFB2
RefSeq ORF Size1245 bp
cDNA DescriptionRhesus TGF-beta 2 Gene ORF cDNA clone expression plasmid, C-GFPSpark tag (CG90036-ACG) - available for purchase from ABclonal - allows for easy subcloning of the ORF (pCMV3-C-GFPSpark Vector) to other plasmid vectors.
SynonymTGF-beta 2, TGFB2
Restriction site
Sequence Description
PromoterEnhanced CMV mammalian cell promoter
Antibiotic in E.coliKanamycin
Antibiotic in mammalian cellHygromycin
Shipping carrierEach tube contains lyophilized plasmid.
StorageThe lyophilized plasmid can be stored at ambient temperature for three months.

Neucleotide sequence and amino acid sequence

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