Product name | Biotinylated Human IL-2 Monoclonal Antibody, Rabbit MAb(DET) |
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Catalog No. | RM17591 |
Catagory | Elisa Antibody Kit |
Application | ELISA |
Description | Interleukin-2 (IL-2) is a O-glycosylated, four alpha -helix bundle cytokine that has potent stimulatory activity for antigen-activated T cells. It is expressed by CD4+ and CD8+ T cells, gamma δ T cells, B cells, dendritic cells, and eosinophils. Mature human IL-2 shares 56% and 66% aa sequence identity with mouse and rat IL-2, respectively. The 55 kDa IL-2 R alpha is specific for IL-2 and binds with low affinity. The 75 kDa IL-2 R beta, which is also a component of the IL-15 receptor, binds IL-2 with intermediate affinity. Upon ligand binding, signal transduction is performed by both IL-2 R beta and gamma c. IL-2 is best known for its autocrine and paracrine activity on T cells. It drives resting T cells to proliferate and induces IL-2 and IL-2 R alpha synthesis. IL-2 plays a central role in the expansion and maintenance of regulatory T cells, although it inhibits the development of Th17 polarized cells. |
Immunogen | Recombinant Human IL2 Protein Ala21-Thr153 Accession #P60568 |
Purirty | Affinity purification |
Ig Type | Rabbit IgG |
Endotoxin Level | < 1.0 EU/μg of the protein by LAL method. |
Formulation | Supplied as a 0.2um filtered solution in PBS with 0.1%Braveds MB-1, PH 7.4. |
CrossReactivity | No cross-reactivity in ELISA with recombinant rmIL-2, rrIL-2, rhIL-2R, rhIL-1a, rhIL-1b, rhIL-2Ra, rhIL-4, rhIL-7, rhIL-9, rhIL-15 |
Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
Human IL-2 Sanwich ELISA Immunoassay
Recommended Concentration | Sample | |
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ELISA Capture | 2-8ug/mL | Human IL-2 Monoclonal Antibody, Rabbit MAb(CAP)(Cat. No. RM17589) |
ELISA Detection | 0.15-0.5ug/mL | Biotinylated Human IL-2 Monoclonal Antibody, Rabbit MAb(DET)(Cat. No. RM17591) |
Standard | 0.78-50pg/mL | Recombinant Human IL2 Protein(Cat. No. RP01039) |
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* For research use only. Not for therapeutic or diagnostic purposes.
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