Product Type > Proteins

Recombinant Mouse TNFRSF4/OX40/CD134 Protein (RP00676)

Datasheet

Overview

Product name Recombinant Mouse TNFRSF4/OX40/CD134 Protein
Catalog No. RP00676
Description Recombinant Mouse TNFRSF4/OX40 Protein is produced by Human Cells expression system. The target protein is expressed with sequence (Val20-Pro211) of mouse TNFRSF4/OX40 (Accession #P47741) fused with an Fc tag at the C-terminus.
Purity > 95% by SDS-PAGE.
Endotoxin < 1 EU/μg of the protein by LAL method.
Formulation Lyophilized from a 0.2 μM filtered solution of PBS, pH 7.4Contact us for customized product form or formulation.
Species Mouse
OX40, also termed CD134 and TNFRSF4, is a T cell co-stimulatory molecule of the TNF receptor superfamilywhich plays a key role in the survival and homeostasis of effector and memory T cells. OX40 is expressed onCD4+ and CD8+ T cells upon engagement of the TCR by antigen presenting cells along with co-stimulation byCD40-CD40 Ligand and CD28-B7. The interaction between OX40 and OX40 ligand (OX40L) will occur whenactivated T cells bind to professional antigen-presenting cells (APCs). The T-cell functions, including cytokineproduction, expansion, and survival, are then enhanced by the OX40 costimulatory signals. OX40 signals arecritical for controlling the function and differentiation of Foxp3+ regulatory T cells. OX40-OX40L interactionregulates T-cell tolerance, peripheral T-cell homeostasis, and T-cell-mediated inflammatory diseases.
Synonym TNFRSF4; OX40; CD134; OX40L receptor; ACT35; TXGP1L; TNFRSF4
Expressed Host HEK293 cells
Tag C-Fc
Swiss-Prot P47741
Gene ID 22163
Storage Store the lyophilized protein at -20°C to -80 °C for long term.
After reconstitution, the protein solution is stable at -20 °C for 3 months, at 2-8 °C for up to 1 week.
Reconstitution Reconstitute to a concentration of 0.1-0.5 mg/mL in 1X PBS.

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