Product Type > Proteins

Recombinant Human TNFSF9/4-1BB Ligand Protein (RP02246)

Datasheet

Overview

Product name Recombinant Human TNFSF9/4-1BB Ligand Protein
Catalog No. RP02246
Purity > 95% by SDS-PAGE.
Formulation Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 19 % trehalose is added as protectants before lyophilization.
Species Human
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This transmembrane cytokine is a bidirectional signal transducer that acts as a ligand for TNFRSF9/4-1BB, which is a costimulatory receptor molecule in T lymphocytes. This cytokine and its receptor are involved in the antigen presentation process and in the generation of cytotoxic T cells. The receptor TNFRSF9/4-1BB is absent from resting T lymphocytes but rapidly expressed upon antigenic stimulation. The ligand encoded by this gene, TNFSF9/4-1BBL, has been shown to reactivate anergic T lymphocytes in addition to promoting T lymphocyte proliferation. This cytokine has also been shown to be required for the optimal CD8 responses in CD8 T cells. This cytokine is expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interaction.
Synonym 4-1BB-L; CD137L; TNLG5A; TNFSF9; CD137L; TNLG5A
Expressed Host HEK293 cells
Tag N-mFc&C-His
Swiss-Prot P41273
Gene ID 8744
Storage Store the lyophilized protein at -20°C to -80°C for long term.
After reconstitution, the protein solution is stable at -20°C for 3 months, at 2-8°C for up to 1 week.
Reconstitution Reconstitute with deionized water

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