Product Type > Proteins

Recombinant Human PDGFR-alpha/CD140a Protein (RP00116)

Datasheet

Overview

Product name Recombinant Human PDGFR-alpha/CD140a Protein
Catalog No. RP00116
Description Recombinant Human PDGFR-alpha/CD140a Protein is produced by HEK293 expression system. The target protein is expressed with sequence (Gln24-Glu524) of human PDGFRa/CD140a (Accession #NP_006197.1) fused with an Fc, 6×His tag at the C-terminus.
Bio-Activity Measured by its binding ability in a functional ELISA. Immobilized recombinant Human PDGF-B at 2 μg/mL (100 μL/well) can bind recombinant Human PDGFRA, the EC50 of Human PDGFRA is 109 ng/mL.
Purity > 97% by SDS-PAGE.
Endotoxin < 0.1 EU/μg of the protein by LAL method.
Formulation Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.Contact us for customized product form or formulation.
Species Human
This protein is a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies suggest that this gene plays a role in organ development, wound healing, and tumor progression. Mutations in this gene have been associated with idiopathic hypereosinophilic syndrome, somatic and familial gastrointestinal stromal tumors, and a variety of other cancers.
Synonym PDGFRA; CD140A; PDGFR-2; PDGFR2; GAS9; RHEPDGFRA
Expressed Host HEK293 cells
Tag C-hFc&His
Swiss-Prot P16234
Gene ID 5156
Storage Store the lyophilized protein at -20°C to -80 °C for long term.
After reconstitution, the protein solution is stable at -20 °C for 3 months, at 2-8 °C for up to 1 week.
Reconstitution Centrifuge the vial before opening. Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. Avoid votex or vigorously pipetting the protein. For long term storage, it is recommended to add a carrier protein or stablizer (e.g. 0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose), and aliquot the reconstituted protein solution to minimize free-thaw cycles.

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