Product Type > Proteins

Recombinant Human B7-H3/CD276 Protein (RP02259)

Datasheet

Overview

Product name Recombinant Human B7-H3/CD276 Protein
Catalog No. RP02259
Description Recombinant Human B7-H3/CD276 Protein is produced by HEK293 cells expression system.The target protein is expressed with human B7-H3 (Leu29-Pro245)&mFc(Pro99-Lys330) (Accession #) fused with a Fc and His Tag at the C-terminal.
Bio-Activity ELISA plate pre-coated by 2 μg/mL (100 μL/well) Human B7-H3, mFc-His tagged protein can bind Anti-B7-H3 Neutralizing antibody in a linear range of 0.24-31.25 ng/mL.
Purity > 95% by SDS-PAGE.
Formulation Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 19 % trehalose is added as protectants before lyophilization.
Species Human
The protein encoded by this gene belongs to the immunoglobulin superfamily, and thought to participate in the regulation of T-cell-mediated immune response. Studies show that while the transcript of this gene is ubiquitously expressed in normal tissues and solid tumors, the protein is preferentially expressed only in tumor tissues. Additionally, it was observed that the 3' UTR of this transcript contains a target site for miR29 microRNA, and there is an inverse correlation between the expression of this protein and miR29 levels, suggesting regulation of expression of this gene product by miR29. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Synonym CD276; 4Ig-B7-H3; B7-H3; B7H3; B7RP-2; CD276 antigen; 4Ig-B7-H3; B7-H3; B7H3; B7RP-2
Expressed Host HEK293 cells
Tag C-mFc&His
Swiss-Prot Q5ZPR3-2
Gene ID 80381
Storage Store the lyophilized protein at -20°C to -80°C for long term.
After reconstitution, the protein solution is stable at -20°C for 3 months, at 2-8°C for up to 1 week.
Reconstitution Reconstitute with deionized water

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