Product Type > Proteins

Recombinant Human FGF23 Protein (RP00366)

Datasheet

Overview

Product name Recombinant Human FGF23 Protein
Catalog No. RP00366
Description Recombinant Human FGF23 Protein is produced by Human Cell expression system. The target protein is expressed with sequence (Tyr25-Ile251) of human FGF23 (Accession #Q9GZV9) fused with a 6×His tag at the C-terminus.
Bio-Activity Measured in a cell proliferation assay using BaF3 mouse pro-B cells transfected with human FGF RIIIc. The ED50 for this effect is 0.1-0.4 μg/mL in the presence of Recombinant Mouse Klotho and heparin.
Purity > 95% by SDS-PAGE.
Endotoxin < 1 EU/μg of the protein by LAL method.
Formulation Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, 1 mM EDTA, 2 mM DTT, pH7.4.Contact us for customized product form or formulation.
Species Human
This protein belongs a member of the fibroblast growth factor family of proteins, which possess broad mitogenic and cell survival activities and are involved in a variety of biological processes. The product of this gene regulates phosphate homeostasis and transport in the kidney. The full-length, functional protein may be deactivated via cleavage into N-terminal and C-terminal chains. Mutation of this cleavage site causes autosomal dominant hypophosphatemic rickets (ADHR). Mutations in this gene are also associated with hyperphosphatemic familial tumoral calcinosis (HFTC).
Synonym FGF23; ADHR; FGFN; HPDR2; HYPF; PHPTC
Expressed Host HEK293 cells
Tag C-6×His
Swiss-Prot Q9GZV9
Gene ID 8074
Storage Store the lyophilized protein at -20°C to -80 °C for long term.
After reconstitution, the protein solution is stable at -20 °C for 3 months, at 2-8 °C for up to 1 week.
Reconstitution Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water.

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