Product Type > Proteins

Recombinant Human IgG4 Fc Protein (RP00804)

Datasheet

Overview

Product name Recombinant Human IgG4 Fc Protein
Catalog No. RP00804
Description Recombinant Human IgG4 Fc Protein is produced by Human Cells expression system. The target protein is expressed with sequence (Glu99-Gly326) of human IgG4 Fc (Accession #P01861).
Purity > 95% by SDS-PAGE.
Endotoxin < 1 EU/μg of the protein by LAL method.
Formulation Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH7.4.Contact us for customized product form or formulation.
Species Human
As a monomeric immunoglobulin that is predominately involved in the secondary antibody response and the only isotypethat can pass through the human placenta, Immunoglobulin G (IgG) is synthesized and secreted by plasma B cells, andconstitutes 75% of serum immunoglobulins in humans. IgG antibodies protect the body against the pathogens byagglutination and immobilization, complement activation, toxin neutralization, as well as the antibody-dependent cell-mediated cytotoxicity (ADCC). IgG tetramer contains two heavy chains (50 kDa ) and two light chains (25 kDa) linked bydisulfide bonds, that is the two identical halves form the Y-like shape. IgG is digested by pepsin proteolysis into Fabfragment (antigen-binding fragment) and Fc fragment ("crystallizable" fragment). IgG1 is most abundant in serum amongthe four IgG subclasses (IgG1, 2, 3 and 4) and binds to Fc receptors (FcγR ) on phagocytic cells with high affinity. Fc fragmentis demonstrated to mediate phagocytosis, trigger inflammation, and target Ig to particular tissues. Protein G or Protein A onthe surface of certain Staphylococcal and Streptococcal strains specifically binds with the Fc region of IgGs, and hasnumerous applications in biotechnology as a reagent for affinity purification. Recombinant IgG Fc Region is suggested torepresent a potential anti-inflammatory drug for treatment of human autoimmune diseases.
Synonym Ig gamma-4 chain C region; IgG4 Fc
Expressed Host HEK293 cells
Tag No tag
Swiss-Prot P01861
Storage Store the lyophilized protein at -20°C to -80 °C for long term.
After reconstitution, the protein solution is stable at -20 °C for 3 months, at 2-8 °C for up to 1 week.
Reconstitution Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water.

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