Product Type > Antibodies > Primary Antibodies > Monoclonal Antibodies

PD-1/CD279 Mouse mAb (A20223)

Datasheet SDS COA

Tested applications: WB IHC-P IF/ICC IP ChIP ChIP-seq RIP FC FC(Intra) ELISA MeDIP Nucleotide Array DB FACS CoIP FCM CUT&Tag meRIP Inhibition

Reactivity:Human, Mouse, Rat

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Overview

Product name PD-1/CD279 Mouse mAb
Catalog No. A20223
Host species Mouse
Purification method Affinity purification
Isotype IgG2b, Kappa
CloneNo. AMC0527

Background

Programmed cell death protein 1 (PDCD1) is an immune-inhibitory receptor expressed in activated T cells; it is involved in the regulation of T-cell functions, including those of effector CD8+ T cells. In addition, this protein can also promote the differentiation of CD4+ T cells into T regulatory cells. PDCD1 is expressed in many types of tumors including melanomas, and has demonstrated to play a role in anti-tumor immunity. Moreover, this protein has been shown to be involved in safeguarding against autoimmunity, however, it can also contribute to the inhibition of effective anti-tumor and anti-microbial immunity.

Immunogen information

Immunogen Recombinant protein of human PD-1/CD279.
Sequence Email for sequence
Gene ID 5133
Swiss prot Q15116
Synonyms PD1; PD-1; CD279; SLEB2; hPD-1; hPD-l; hSLE1; PD-1/CD279
Calculated MW 32kDa
Observed MW 52-65kDa

Applications

Reactivity Human, Mouse, Rat
Tested applications WB IHC-P IF/ICC IP ChIP ChIP-seq RIP FC FC(Intra) ELISA MeDIP Nucleotide Array DB FACS CoIP FCM CUT&Tag meRIP Inhibition
Recommended dilution
  • WB 1:500 - 1:1000
Storage buffer Store at -20℃. Avoid freeze / thaw cycles.
Buffer: PBS with 0.05% proclin300, 50% glycerol, pH7.3.
Application key Western blotting    
Positive samples Molt-4, Jurkat, Mouse spleen, Mouse thymus, Rat lung
Cellular location Membrane, Single-pass type I membrane protein

Documents

Certificate of Compliance

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Lot number

Research Area

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Related Targets

Based on existing publications, the following genes are closely related to research on PDCD1. (Numbers indicate number of published articles where both targets appear.)

1/

Related Research Area

Based on existing publications, the following research topics are related to PDCD1. (Distance between topics and target gene indicate popularity.) PDCD1

* Data provided by citexs.com, for reference only.

Publishing research using A20223? Please let us know so that we can cite the reference in this datasheet.

Antibodies (3)

Proteins (5)

Secondary Antibodies (17)

* For research use only. Not for therapeutic or diagnostic purposes.

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