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FMR1 Rabbit pAb (A6092)

Datasheet

ABclonal:Western blot - FMR1 Polyclonal Antibody (A6092)
ABclonal:Immunohistochemistry - FMR1 Polyclonal Antibody (A6092)
ABclonal:Immunohistochemistry - FMR1 Polyclonal Antibody (A6092)
ABclonal:Immunohistochemistry - FMR1 Polyclonal Antibody (A6092)

Overview

Product nameFMR1 Rabbit pAb
Catalog No.A6092
Host speciesRabbit
Purification methodAffinity purification
IsotypeIgG
The protein encoded by this gene binds RNA and is associated with polysomes. The encoded protein may be involved in mRNA trafficking from the nucleus to the cytoplasm. A trinucleotide repeat (CGG) in the 5' UTR is normally found at 6-53 copies, but an expansion to 55-230 repeats is the cause of fragile X syndrome. Expansion of the trinucleotide repeat may also cause one form of premature ovarian failure (POF1). Multiple alternatively spliced transcript variants that encode different protein isoforms and which are located in different cellular locations have been described for this gene.
ImmunogenA synthetic peptide corresponding to a sequence within amino acids 500-600 of human FMR1 (NP_002015.1).
SequenceSETESDHRDELSDWSLAPTEEERESFLRRGDGRRRGGGGRGQGGRGRGGGFKGNDDHSRTDNRPRNPREAKGRTTDGSLQIRVDCNNERSVHTKTLQNTSS
Gene ID2332
Swiss protQ06787
SynonymsFMRP; FRAXA; POF; POF1; FMR1; POFX
Calculated MW58kDa/61kDa/66kDa/68kDa/69kDa/70kDa/71kDa
Observed MW71kDa
ReactivityHuman, Mouse, Rat
Tested applicationsWBIHCICCIFIPChIPChIPseqRIPFCELISAMeDIPNucleotide Array
Recommended dilutionWB 1:500 - 1:1000
IHC 1:50 - 1:200
IF 1:100 - 1:200
Storage bufferStore at -20℃. Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Application keyWestern blotting    Immunohistochemistry    Immunofluorescence    
Positive samplesU-251MG, HeLa, Rat brain
Cellular locationCytoplasm, Nucleus, nucleolus
ABclonal:Western blot - FMR1 Polyclonal Antibody (A6092) }

Western blot - FMR1 Polyclonal Antibody (A6092)

Western blot analysis of extracts of various cell lines, using FMR1 antibody (A6092) at 1:1000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit (RM00020).
Exposure time: 10s.
ABclonal:Immunohistochemistry - FMR1 Polyclonal Antibody (A6092) }

Immunohistochemistry - FMR1 Polyclonal Antibody (A6092)

Immunohistochemistry of paraffin-embedded rat lung using FMR1 antibody (A6092) at dilution of 1:100 (40x lens).
ABclonal:Immunohistochemistry - FMR1 Polyclonal Antibody (A6092) }

Immunohistochemistry - FMR1 Polyclonal Antibody (A6092)

Immunohistochemistry of paraffin-embedded mouse testis using FMR1 antibody (A6092) at dilution of 1:100 (40x lens).
ABclonal:Immunohistochemistry - FMR1 Polyclonal Antibody (A6092) }

Immunohistochemistry - FMR1 Polyclonal Antibody (A6092)

Immunohistochemistry of paraffin-embedded mouse brain using FMR1 antibody (A6092) at dilution of 1:100 (40x lens).

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