Tumor necrosis factor receptor superfamily member 27, also known as X-linked ectodysplasin-A2 receptor, EDA-A2 receptor, EDA2R, XEDAR and TNFRSF27, is a single-pass type I II membrane protein. TNFRSF27 / EDA2R contains three TNFR-Cys repeats. It is a new member of the tumor necrosis factor receptor family that has been shown to be highly expressed in ectodermal derivatives during embryonic development and binds to ectodysplasin-A2 (EDA-A2). TNFRSF27 / EDA2R is a receptor for EDA isoform A2, but not for EDA isoform A1. TNFRSF27 / EDA2R mediates the activation of the NF-kappa-B and JNK pathways. The activation seems to be mediated by binding to TRAF3 and TRAF6. Ectodysplasin, a member of the tumor necrosis factor family, is encoded by the anhidrotic ectodermal dysplasia EDA gene. Mutations in EDA give rise to a clinical syndrome characterized by loss of hair, sweat glands, and teeth. EDA-A1 and EDA-A2 are two isoforms of ectodysplasin that differ only by an insertion of two amino acids. This insertion functions to determine receptor binding specificity, such that EDA-A1 binds only the receptor EDAR, whereas EDA-A2 binds only the related, but distinct, X-linked ectodysplasin-A2 receptor (XEDAR).
Human XEDAR/EDA2R Gene ORF cDNA clone expression plasmid Product information
|RefSeq ORF Size||894 bp|
|cDNA Description||Human XEDAR/EDA2R Gene ORF cDNA clone expression plasmid (HG11845-UT) - available for purchase from ABclonal - allows for easy subcloning of the ORF (pCMV3-untagged Vector) to other plasmid vectors.|
|Synonym||EDA-A2R, EDAA2R, TNFRSF27, XEDAR|
|Restriction site||HindIII + XbaI (6.1kb + 0.89kb)|
|Sequence Description||Identical with the Gene Bank Ref. ID sequence.|
|Sequencing primers||T7(TAATACGACTCACTATAGGG) BGH(TAGAAGGCACAGTCGAGG)|
|Promoter||Enhanced CMV mammalian cell promoter|
|Antibiotic in E.coli||Ampicillin|
|Antibiotic in mammalian cell||Hygromycin|
|Shipping carrier||Each tube contains lyophilized plasmid.|
|Storage||The lyophilized plasmid can be stored at ambient temperature for three months.|
Human XEDAR/EDA2R Gene ORF cDNA clone expression plasmid images
Cynomolgus CD19/B4/CVID3 Gene Plasmid Map
Neucleotide sequence and amino acid sequence
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