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Meet Dr. Beaker at ABclonal

  • 11/12023

    Case Western Reserve University

  • 11/22023

    Cleveland Clinic

  • 11/42023

    Houston Nutrition & Obesity Research Symposium

  • Dec.3-52023

    An ASCB | EMBO Meeting: Cell Bio 2023

FEATURED ARTICLES

Structural insights into preinitiation complex assembly on core promoters

Journal: Science

Publication Date: 4/1/2021

PubMed ID: 33795473

Referenced Products: TBP Rabbit pAb (A2192), POLR2B Rabbit pAb (A5928)

Sample Species: Homo sapien

Application: WB

Molecular basis of nucleosomal H3K36 methylation by NSD methyltransferases

Journal: Nature

Publication Date: 12/23/2020

PubMed ID: 33361816

Referenced Products: H3K36me1 Rabbit pAb (A2364)

Sample Species: Homo sapien

Application: WB

SPT5 stabilizes RNA polymerase II, orchestrates transcription cycles, and maintains the enhancer landscape

Journal: Molecular Cell

Publication Date: 9/10/2021

PubMed ID: 34534457

Referenced Products: Vinculin Rabbit mAb (A2752), H3K25ac1 Rabbit pAb (A7253), SUPT4H1 Rabbit pAb (A7933)

Sample Species: Homo sapien

Application: WB

Cancer cells escape autophagy inhibition via NRF2-induced macropinocytosis

Journal: Cancer Cell

Publication Date: 3/18/2021

PubMed ID: 33740421

Referenced Products: NRF2 Rabbit pAb (A11159)

Sample Species: Mus muculus

Application: WB

Targeting mitochondria-located circRNA SCAR alleviates NASH via reducing mROS output

Journal: Cell

Publication Date: 9/14/2020

PubMed ID: 32931733

Referenced Products: RNASEL Rabbit pAb (A9840)

Sample Species: Homo sapien

Application: WB

LATEST BLOGS
  • The Unsung Hero: Maurice Hilleman, Father of Vaccines

    Having navigated the worst of a pandemic, it is amazing how just barely over a year since the first reports of SARS-CoV-2, a vaccine was developed. What might not be as well known is that the foundation for the COVID-19 vaccine (and a just-as-rapid quell of the spread, though obviously still be vigilant and take proper precautions) was laid out for decades with the study of mRNA-based vaccines. Although I still masked up regularly until early 2023, I was thrilled to have the opportunity to get the vaccine as soon as it was available in 2021, as my family and I sought to protect ourselves and others through a day or two of aches and nausea. The scientists and technicians at the various companies that conceived of and manufactured the vaccines that have been distributed across the planet are relatively anonymous but should be commended. August being National Immunization Awareness Month, let us learn a bit more about vaccination and the pioneers that offer us important protections that we should not take for granted.

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  • The Progressive March Toward Equality

    By the time I returned to graduate school to complete my PhD, the entering class in my program was half women and a large portion of my instructors were also women. I was encouraged to have access to their perspective and philosophies on science, and thought it a far cry from a decade before when most of my undergraduate instructors were men. Unfortunately, regardless of who is doing the reporting, although women do make up a good proportion of health care workers and just under half of all life science positions in the workforce, women comprise less than 30% of all STEM workers in the world, and since they are nudged away from science throughout their lives and careers while earning fewer STEM degrees than men, particularly in non-physical science fields. This is demonstrably worse for non-Asian minorities as their representation in STEM fields is under 10% overall. While I am thrilled to have been influenced by so many talented women scientists and colleagues in my career, these numbers can and should be improved.

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  • The Nature of Being Sinister: The Genetics of Left-Handedness

    Left-handed folks aren't as rare as people with polydactyly or syndactyly (webbed hands or feet), but you may have noticed that there aren't as many left-handed people out there as right-handed people. Some of this is due to societal pressures, but I was intrigued to learn that much of it may have to do with genetics, and these genetic mechanisms may extend not just to which hand is dominant, but how the body plan is determined. Like many things in bioscience, it isn't always apparent that handedness and its genetic components are critical to other aspects of physiology, but as we will find out together, the genes associated with whether you use one hand more efficiently than the other can also influence developmental and neurological health!

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  • Fanzor: The Next Step in Gene Editing?

    I was recording a new BioChat (you should subscribe) recently with a professor at Harvard. We discussed gene therapy in passing for the disease he was studying, and one of the things that he brought up was the need to ensure that whatever therapy is designed has to be safe and effective. This of course is the promise and also the challenge of CRISPR-based research, in which the model is known but the targeting efficiency isn't where it needs to be in order to be of practical use in therapeutics. This is a big reason why the biomedical research world was abuzz with the recent announcement (and preprint) of a major discovery by scientists at the Broad Institute, where they characterized the mechanisms and the potential utility of a system similar to CRISPR in eukaryotes. 

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