|Synonym||ACVRLK1, ALK-1, ALK1, HHT, HHT2, ORW2, SKR3, TSR-I|
|Protein Construction||High quality, high purity and low endotoxin recombinant Human ALK-1 / ACVRL1 Protein (Fc Tag) (10066-H02H), tested reactivity in Human and has been validated in SDS-PAGE.100% guaranteed.|
|Expressed Host||Human Cells|
|Shipping||In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.|
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
|Purity||> 97 % as determined by SDS-PAGE|
|Bio-Activity||1. Measured by its ability to bind Human ENG-Fc (Cat:10149-H02H) in functional Elisa. 2. Measured by its ability to latent TGFB1-His (Cat:10804-H08H) in functional Elisa. 3. Measured by its ability to mouse ENG-His (Cat:50407-M08H) in functional Elisa. 4. Measured by its ability to inhibit BMP9 induced alkaline phosphatase production by MC3T3E1 mouse chondrogenic cells. David, L. et al. (2007) Blood 109:1953. The ED50 for this effect is typically 5-15 ng/mL in the presence of 2 ng/mL of recombiant human BMP9.|
|Endotoxin||< 1.0 EU per μg of the protein as determined by the LAL method|
|Stability||Samples are stable for up to twelve months from date of receipt at -70℃|
|Predicted N Terminal||Asp 22|
|Molecule Mass||The mature recombinant human ALK1/Fc chimera is a disulfide-linked homodimeric protein. The reduced monomer comprises 335 amino acids and has a predicted molecular mass of 37.4 kDa. As a result of glycosylation, the recombinant monomer migrates as an approximately 45-50 kDa protein in SDS-PAGE under reducing conditions.|
|Storage||Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.|
|Reconstitution||A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.|
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