Summary
Catalog No:A10963
Host species:Rabbit
Purity:Affinity purification
Isotype:IgG
ABclonal:Western blot - LRP1 antibody (A10963)
ABclonal:Immunohistochemistry  - LRP1 antibody (A10963)
ABclonal:Immunohistochemistry  - LRP1 antibody (A10963)
ABclonal:Immunohistochemistry  - LRP1 antibody (A10963)
ABclonal:Immunohistochemistry  - LRP1 antibody (A10963)
ABclonal:Immunofluorescence - LRP1 antibody (A10963)
ABclonal:Immunofluorescence - LRP1 antibody (A10963)
ABclonal:Immunofluorescence - LRP1 antibody (A10963)

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Background

This gene encodes a member of the low-density lipoprotein receptor family of proteins. The encoded preproprotein is proteolytically processed by furin to generate 515 kDa and 85 kDa subunits that form the mature receptor (PMID: 8546712). This receptor is involved in several cellular processes, including intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. In addition, the encoded protein is necessary for the alpha 2-macroglobulin-mediated clearance of secreted amyloid precursor protein and beta-amyloid, the main component of amyloid plaques found in Alzheimer patients. Expression of this gene decreases with age and has been found to be lower than controls in brain tissue from Alzheimer's disease patients.

Immunogen information

ImmunogenRecombinant protein of human LRP1
SequenceEmail for sequence
Gene ID4035
Swiss ProtQ07954
SynonymsA2MR, APOER, APR, CD91, IGFBP3R, KPA, LRP, LRP1A, TGFBR5, A2MR, APOER, APR, CD91, IGFBP3R, LRP, LRP1A, TGFBR5
Calculated MW31kDa/504kDa
Observed MW78kDa

Applications

ReactivityHuman, Mouse, Rat
Tested applicationsWB, IHC, IF, IP
Recommended DilutionWB 1:10000 - 1:20000
IHC 1:50 - 1:100
IF 1:50 - 1:100
IP 1:20 - 1:50
Storage BufferStore at -20℃. Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Application keyWestern blotting    Immunohistochemistry    Immunofluorescence    Immunoprecipitation    
Positive samples
Cellular LocationCell membrane, Cytoplasm, Extracellular side, Membrane, Nucleus, Peripheral membrane protein, Single-pass type I membrane protein, coated pit
Customer Validation

WB (Human)

LRP1 Monoclonal Antibody images

ABclonal:Western blot - LRP1 antibody (A10963)

Western blot - LRP1 antibody (A10963)

Western blot analysis of extracts of various cell lines, using LRP1 antibody (A10963).
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
ABclonal:Immunohistochemistry  - LRP1 antibody (A10963)

Immunohistochemistry - LRP1 antibody (A10963)

Immunohistochemistry of paraffin-embedded mouse brain using LRP1 antibody (A10963) at dilution of 1:100 (40x lens).
ABclonal:Immunohistochemistry  - LRP1 antibody (A10963)

Immunohistochemistry - LRP1 antibody (A10963)

Immunohistochemistry of paraffin-embedded human liver using LRP1 antibody (A10963) at dilution of 1:100 (40x lens).
ABclonal:Immunohistochemistry  - LRP1 antibody (A10963)

Immunohistochemistry - LRP1 antibody (A10963)

Immunohistochemistry of paraffin-embedded human lung using LRP1 antibody (A10963) at dilution of 1:100 (40x lens).
ABclonal:Immunohistochemistry  - LRP1 antibody (A10963)

Immunohistochemistry - LRP1 antibody (A10963)

Immunohistochemistry of paraffin-embedded mouse liver using LRP1 antibody (A10963) at dilution of 1:100 (40x lens).
ABclonal:Immunofluorescence - LRP1 antibody (A10963)

Immunofluorescence - LRP1 antibody (A10963)

Immunofluorescence analysis of MCF-7 cells using LRP1 antibody (A10963).
ABclonal:Immunofluorescence - LRP1 antibody (A10963)

Immunofluorescence - LRP1 antibody (A10963)

Immunofluorescence analysis of HeLa cells using LRP1 antibody (A10963).
ABclonal:Immunofluorescence - LRP1 antibody (A10963)

Immunofluorescence - LRP1 antibody (A10963)

Immunofluorescence analysis of HUVEC cells using LRP1 antibody (A10963).

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