Product Type > Antibodies > Primary Antibodies > Monoclonal Antibodies

JAK1 Rabbit mAb (A11878)

Datasheet SDS

Tested applications: WB IHC-P IF/ICC IP ChIP ChIP-seq RIP FC FC(Intra) ELISA MeDIP Nucleotide Array DB FACS CoIP FCM CUT&Tag meRIP Inhibition

Reactivity:Human, Mouse, Rat

ABclonal:Western blot - JAK1 Rabbit mAb (A11878)

Western blot analysis of extracts of various cell lines, using JAK1 antibody (A11878).
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.
Lysates/proteins: 25μg per lane.
Blocking buffer: 3% nonfat dry milk in TBST.

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Overview

Product name JAK1 Rabbit mAb
Catalog No. A11878
Host species Rabbit
Purification method Affinity purification
Isotype IgG

Background

This gene encodes a membrane protein that is a member of a class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The encoded kinase phosphorylates STAT proteins (signal transducers and activators of transcription) and plays a key role in interferon-alpha/beta, interferon-gamma, and cytokine signal transduction. This gene plays a crucial role in effecting the expression of genes that mediate inflammation, epithelial remodeling, and metastatic cancer progression. This gene is a key component of the interleukin-6 (IL-6)/JAK1/STAT3 immune and inflammation response and is a therapeutic target for alleviating cytokine storms. The kinase activity of this gene is directly inhibited by the suppressor of cytokine signalling 1 (SOCS1) protein. Alternative splicing results in multiple transcript variants.

Immunogen information

Immunogen Recombinant protein of human JAK1
Sequence Email for sequence
Gene ID 3716
Swiss prot P23458
Synonyms JTK3; AIIDE; JAK1A; JAK1B; JAK1
Calculated MW 133kDa
Observed MW 133kDa

Applications

Reactivity Human, Mouse, Rat
Tested applications WB IHC-P IF/ICC IP ChIP ChIP-seq RIP FC FC(Intra) ELISA MeDIP Nucleotide Array DB FACS CoIP FCM CUT&Tag meRIP Inhibition
Recommended dilution
  • WB 1:500 - 1:2000
  • IHC-P 1:50 - 1:100
Storage buffer Store at -20℃. Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Application key Western blotting    Immunohistochemistry    
Positive samples ACHN, SR, CTLL-2, PC-12
Cellular location Endomembrane system, Peripheral membrane protein

Research Area

JAK1 Rabbit mAb images

ABclonal:Western blot - JAK1 Rabbit mAb (A11878)}

Western blot - JAK1 Rabbit mAb (A11878)

Western blot analysis of extracts of various cell lines, using JAK1 antibody (A11878).
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.
Lysates/proteins: 25μg per lane.
Blocking buffer: 3% nonfat dry milk in TBST.

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Related Targets

Based on existing publications, the following genes are closely related to research on JAK1. (Numbers indicate number of published articles where both targets appear.)

1/

Related Research Area

Based on existing publications, the following research topics are related to JAK1. (Distance between topics and target gene indicate popularity.) JAK1

* Data provided by citexs.com, for reference only.

Publishing research using A11878? Please let us know so that we can cite the reference in this datasheet.

Antibodies (4)

ELISA Kits (1)

Secondary Antibodies (23)

* For research use only. Not for therapeutic or diagnostic purposes.

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